Evidence map›Paper›PMID 31552055›Full record

ArticleFrontiers in immunology2019

Immunophenotype of a Rat Model of Duchenne's Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment.

Laure-Hélène Ouisse, Séverine Remy, Aude Lafoux, Thibaut Larcher, Laurent Tesson, Vanessa Chenouard, Carole Guillonneau, Lucas Brusselle, Nadège Vimond, Karl Rouger and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Cardiovascular phenotype of theDisease models & mechanisms · 2021
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Laure-Hélène OuisseCentre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.
Séverine RemyCentre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.
Aude LafouxTHERASSAY CAPACITES, Université de Nantes, Nantes, France.
Thibaut LarcherINRA, UMR703 APEX, Oniris, Ecole Nationale Vétérinaire, Agro-alimentaire et de l'alimentation, Nantes, France.
Laurent TessonCentre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.
Vanessa ChenouardCentre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.
Carole GuillonneauCentre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.
Lucas BrusselleCentre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.
Nadège VimondCentre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.
Karl RougerINRA, UMR703 APEX, Oniris, Ecole Nationale Vétérinaire, Agro-alimentaire et de l'alimentation, Nantes, France.
Yann PéréonReference Centre for Neuromuscular Diseases AOC, CHU Nantes, Nantes, France.
Alexis ChenouardPediatric Intensive Care, Hôpital Mère Enfant, CHU Nantes, Nantes, France.
Christèle Gras-Le GuenClinical Investigation Center 1413 INSERM 1043, CHU Nantes, Nantes, France.
Cécile BraudeauCentre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.
Régis JosienCentre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.
Corinne HuchetTHERASSAY CAPACITES, Université de Nantes, Nantes, France.
Ignacio AnegonCentre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.
Nantes Université · FRInstitut de Transplantation Urologie en Nephrologie · FRInserm · FROniris · FRGene Therapy Laboratory · FRHôpital Mère-Enfant · FRTransgene (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corticosteroids (CS) are standard therapy for the treatment of Duchenne's muscular dystrophy (DMD). Even though they decrease inflammation, they have limited efficacy and are associated with significant side effects. There is therefore the need for new protolerogenic treatments to replace CS. Dystrophin-deficient rats (

Indexed as

AnimalsAntibodies, MonoclonalCytokinesDisease Models, AnimalImmunophenotypingLeukocyte Common AntigensMacrophagesMuscle, SkeletalMuscle StrengthMuscular Dystrophy, DuchenneRatsSpleenT-LymphocytesAntibodies, MonoclonalCytokinesLeukocyte Common Antigensdystrophinimmunosuppressionknockout ratsmuscle injurynucleasesTALENtoleranceTreg

Identifiers

PMID31552055
PMCPMC6746111
OpenAlexW2969994091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.