Evidence map›Paper›PMID 31552035›Full record

ArticleFrontiers in immunology2019

NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation.

Sarah E Clark, Kristina S Burrack, Stephen C Jameson, Sara E Hamilton, Laurel L Lenz

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. The role of CD8Heliyon · 2024
    Review
  9. Article
  10. Natural killer cells in the central nervous system.Cell communication and signaling : CCS · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. NK Cell-Derived IL-10 Supports Host Survival during Sepsis.Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
  16. Review
  17. Review
  18. Review
  19. IL-10-producing NK cells exacerbate sublethal Streptococcus pneumoniae infection in the lung.Translational research : the journal of laboratory and clinical medicine · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sarah E ClarkDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, United States.
Kristina S BurrackDepartment of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN, United States.
Stephen C JamesonDepartment of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN, United States.
Sara E HamiltonDepartment of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN, United States.
Laurel L LenzDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, United States.
University of Minnesota Medical Center · USUniversity of Colorado Denver · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
Immune Modulation by Bacterial AutolysinsR01AI065638 · NIAID · UNIVERSITY OF COLORADO DENVER · PI LENZ, LAUREL L · 2006 to 2016
$3.8M
NK cell IL-10 production during bacterial infectionsR01AI131662 · NIAID · UNIVERSITY OF COLORADO DENVER · PI LENZ, LAUREL L · 2017 to 2021
$2.9M
Regulation of the Immune Response to Plasmodium by IL-10 Producing Natural Killer CellsR01AI143828 · NIAID · UNIVERSITY OF MINNESOTA · PI HAMILTON HART, SARA ELIZABETH · 2019 to 2023
$2.3M
The impact of IL-4 on the CD8 T cell response to pathogensR21AI100088 · NIAID · UNIVERSITY OF MINNESOTA · PI JAMESON, STEPHEN C · 2012 to 2013
$418k
Protection from cerebral malaria in mice by cytokine-stimulated NK cellsF32AI120312 · NIAID · UNIVERSITY OF MINNESOTA · PI BURRACK, KRISTINA STOERMER · 2015 to 2017
$168k
NCI NIH HHS P30 CA077598NIAID NIH HHS F32 AI120312NIAID NIH HHS R01 AI065638NIAID NIH HHS R01 AI131662NIAID NIH HHS R01 AI143828NIAID NIH HHS R21 AI100088
6 · The paper itself

Abstract

Natural killer (NK) cells can produce IFNγ or IL-10 to regulate inflammation and immune responses but the factors driving NK cell IL-10 secretion are poorly-defined. Here, we identified NK cell-intrinsic STAT3 activation as vital for IL-10 production during both systemic

Indexed as

AnimalsGene ExpressionHost-Pathogen InteractionsInterferon-gammaInterleukin-10Interleukin-15Killer Cells, NaturalListeria monocytogenesListeriosisMalaria, CerebralMice, Inbred C57BLMice, KnockoutMice, TransgenicSTAT3 Transcription FactorSurvival AnalysisInterferon-gammaInterleukin-10Interleukin-15STAT3 Transcription Factorcerebral malariaIL-10IL-15IL-15 complexListeria (L.) monocytogenesNK cellPlasmodiumStat3

Identifiers

PMID31552035
PMCPMC6736993
OpenAlexW2969895789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.