Evidence map›Paper›PMID 31552024›Full record

ArticleFrontiers in immunology2019

Mice Deficient in Epithelial or Myeloid Cell Iκκβ Have Distinct Colonic Microbiomes and Increased Resistance to

Amy R Mackos, Jacob M Allen, Eunsoo Kim, Chris A Ladaika, Raad Z Gharaibeh, Cathy Moore, Nicola M A Parry, Prosper N Boyaka, Michael T Bailey

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Amy R MackosCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.
Jacob M AllenCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.
Eunsoo KimDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Chris A LadaikaCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.
Raad Z GharaibehDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, United States.
Cathy MooreDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, United States.
Nicola M A ParryDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, United States.
Prosper N BoyakaDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Michael T BaileyCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.
Nationwide Children's Hospital · USThe Ohio State University · USUniversity of North Carolina at Charlotte · USMassachusetts Institute of Technology · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Comprehensive Training in Oral &Craniofacial SciencesT32DE014320 · NIDCR · OHIO STATE UNIVERSITY · PI SHERIDAN, JOHN F · 2001 to 2022
$10.2M
Role of stress-induced reduction in Lactobacillus reuteri on colonic inflammationR01AT006552 · NCCIH · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BAILEY, MICHAEL T · 2012 to 2016
$1.9M
NCCIH NIH HHS R01 AT006552NCI NIH HHS P30 CA016058NIDCR NIH HHS T32 DE014320
6 · The paper itself

Abstract

The colonic microenvironment, stemming from microbial, immunologic, stromal, and epithelial factors, serves as an important determinant of the host response to enteric pathogenic colonization. Infection with the enteric bacterial pathogen

Indexed as

Gastrointestinal MicrobiomeAnimalsCitrobacter rodentiumColitisCytokinesDisease Models, AnimalDisease ResistanceDisease SusceptibilityEnterobacteriaceae InfectionsGene ExpressionI-kappa B KinaseLymph NodesMacrophagesMaleMiceMice, KnockoutCytokinesI-kappa B KinaseCitrobacter rodentiumcolitiscolonic epithelial cellsmicrobiotaNF-κB

Identifiers

PMID31552024
PMCPMC6746829
OpenAlexW2972966807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.