ArticleFrontiers in immunology2019
Neonatal Exposure to Amoxicillin Alters Long-Term Immune Response Despite Transient Effects on Gut-Microbiota in Piglets.
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 36 citations in OpenAlex.
- Prevalence and risk factors of recurrent respiratory tract infections in preschool children: a systematic review and meta-analysis.Jornal de pediatria · 2026Review
- Comment: Short-term benefit or long-term harm? Enteral antibiotics, intestinal inflammation, and immune trade-offs.Pediatric research · 2026Article
- A manually curated pig gut microbiome dataset for precision feeding.Scientific data · 2026Article
- Impact of Diet and Maternal Obesity on Human Milk Hyaluronan.Nutrients · 2025Article
- Microbiota profiles and antimicrobial resistance genes in sow fecal samples from farms with and without antibiotic use.Animal bioscience · 2025Article
- Hepatotoxicity and Antimicrobial Resistance to Amoxicillin and Amoxicillin/Clavulanic Acid: Data Analysis from EudraVigilance.Molecules (Basel, Switzerland) · 2025Article
- From mother to piglet: the lasting influence of the maternal microbiome.Animal microbiome · 2025Article
- Control of Neonatal Diarrhea in Piglets with Reduced Antibiotic Use by Application of a Complementary Feed-A Randomized Controlled Farm Trial.Veterinary sciences · 2025Article
- The Roadmap of Plant Antimicrobial Peptides Under Environmental Stress: From Farm to Bedside.Probiotics and antimicrobial proteins · 2024Review
- Effects of Probiotic-Fermented Feed on the Growth Profile, Immune Functions, and Intestinal Microbiota of Bamei Piglets.Animals : an open access journal from MDPI · 2024Article
- The Effect of Maternal Probiotic or Synbiotic Supplementation on Sow and Offspring Gastrointestinal Microbiota, Health, and Performance.Animals : an open access journal from MDPI · 2023Review
- Research progress on anti-stress nutrition strategies in swine.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Review
- Microbial Interventions to Improve Neonatal Gut Health.Microorganisms · 2023Review
- Treatment of Mouse Infants with Amoxicillin, but Not the Human Milk-Derived Antimicrobial HAMLET, Impairs Lung Th17 Responses.Antibiotics (Basel, Switzerland) · 2023Article
- Weaning transition, but not the administration of probiotic candidateFrontiers in veterinary science · 2023Article
- Post-weaning diarrhea in pigs from a single Danish production herd was not associated with the pre-weaning fecal microbiota composition and diversity.Frontiers in microbiology · 2023Article
- Maternal Mycobiome, but Not Antibiotics, Alters Fungal Community Structure in Neonatal Piglets.Applied and environmental microbiology · 2022Article
- Recovery of the Structure and Function of the Pig Manure Bacterial Community after Enrofloxacin Exposure.Microbiology spectrum · 2022Article
- Effect of amino acid blend as alternative to antibiotics for growing pigs.Journal of animal science · 2022Article
- Linking Animal Welfare and Antibiotic Use in Pig Farming-A Review.Animals : an open access journal from MDPI · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
Antibiotic exposure during neonatal development may result in transient or persistent alterations of key microbes that are vital for normal development of local and systemic immunity, potentially impairing immune competence later in life. To further elucidate the relationship between antibiotic exposure and immune development, newborn pigs were exposed to a therapeutic pediatric dose (30 mg/kg/day) of amoxicillin (AB) or placebo (PL) from post-natal day (PND) 0-14. Subsequently, immune cell phenotype, microbial composition, and immune response to an intraperitoneal (IP) challenge with
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.