Evidence map›Paper›PMID 31551806›Full record

ArticleFrontiers in physiology2019

Multi-Day Prolonged Low- to Moderate-Intensity Endurance Exercise Mimics Training Improvements in Metabolic and Oxidative Profiles Without Concurrent Chromosomal Changes in Healthy Adults.

Dominique D Gagnon, Sandra Dorman, Stephen Ritchie, Shivaprakash Jagalur Mutt, Ville Stenbäck, Jarosław Walkowiak, Karl-Heinz Herzig

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Effect of Tai Chi on Markers of Oxidative Stress: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Dominique D GagnonLaboratory of Environmental Exercise Physiology, School of Human Kinetics, Laurentian University, Sudbury, ON, Canada.
Sandra DormanLaboratory of Environmental Exercise Physiology, School of Human Kinetics, Laurentian University, Sudbury, ON, Canada.
Stephen RitchieLaboratory of Environmental Exercise Physiology, School of Human Kinetics, Laurentian University, Sudbury, ON, Canada.
Shivaprakash Jagalur MuttResearch Unit of Biomedicine, Department of Physiology and Biocenter of Oulu, University of Oulu, Oulu, Finland.
Ville StenbäckResearch Unit of Biomedicine, Department of Physiology and Biocenter of Oulu, University of Oulu, Oulu, Finland.
Jarosław WalkowiakDepartment of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznań, Poland.
Karl-Heinz HerzigResearch Unit of Biomedicine, Department of Physiology and Biocenter of Oulu, University of Oulu, Oulu, Finland.
Laurentian University · CAPoznan University of Medical Sciences · PLNOSM University · CAOulu University Hospital · FIUniversity of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOxidative stress results in lipid, protein, and DNA oxidation, resulting in telomere erosion, chromosomal damage, and accelerated cellular aging. Training promotes healthy metabolic and oxidative profiles whereas the effects of multi-day, prolonged, and continuous exercise are unknown. This study investigated the effects of multi-day prolonged exercise on metabolic and oxidative stress as well as telomere integrity in healthy adults.

methodsFifteen participants performed a 14-day, 260-km, wilderness canoeing expedition (12 males) (EXP) (24 ± 7 years, 72 ± 6 kg, 178 ± 8.0 cm, 18.4 ± 8.4% BF, 47.5 ± 9.3 mlO

resultsSerum cholesterol, high- and low-density lipoprotein, testosterone, insulin, sodium, potassium, urea, and chloride concentrations were not different between groups, whereas triglycerides, glucose, and creatinine levels were lower following the expedition (

conclusionThese results indicate a modest improvement in metabolic and oxidative profiles with increased superoxidase dismutase levels, suggesting an antioxidative response to counteract the exercise-associated production of free radicals and reactive oxygen species during prolonged exercise, mimicking the effects from long-term training. Although improved antioxidant activity may lead to increased TL, the present exercise stimulus was insufficient to promote a positive cellular aging profile with concordant chromosomal changes in our healthy and young participants.

Indexed as

hormonesmetabolismoxidative stressprolonged exercisetelomeres

Identifiers

PMID31551806
PMCPMC6733972
OpenAlexW2966907340

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.