Evidence map›Paper›PMID 31551712›Full record

ArticleFrontiers in cellular neuroscience2019

Stem Cell-Derived Exosomes Protect Astrocyte Cultures From

Xiaoyun Sun, Ji-Hye Jung, Oiva Arvola, Michelle R Santoso, Rona G Giffard, Phillip C Yang, Creed M Stary

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 5 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 5 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke.Frontiers in bioengineering and biotechnology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiaoyun SunDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Ji-Hye JungDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Oiva ArvolaDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Michelle R SantosoDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Rona G GiffardDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Phillip C YangDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Creed M StaryDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Stanford University · US

Funding

Cell Characterization and Imaging for Regenerative Therapies in Ischemic DiseasesUM1HL113456 · NHLBI · STANFORD UNIVERSITY · PI YANG, PHILLIP CHUNG-MING · 2012 to 2018
$3.3M
Stress Proteins in Brain Cell InjuryR01NS084396 · NINDS · STANFORD UNIVERSITY · PI GIFFARD, RONA G · 2013 to 2017
$1.7M
Patient Oriented Research in Cardiovascular RegenerationK24HL130553 · NHLBI · STANFORD UNIVERSITY · PI YANG, PHILLIP CHUNG-MING · 2016 to 2020
$584k
NHLBI NIH HHS K24 HL130553NHLBI NIH HHS UM1 HL113456NINDS NIH HHS R01 NS084396
6 · The paper itself

Abstract

In the present study, we assessed efficacy of exosomes harvested from human and mouse stem cell cultures in protection of mouse primary astrocyte and neuronal cell cultures following

Indexed as

cerebral ischemiagliaiCMiPSCMCAOpluripotent

Identifiers

PMID31551712
PMCPMC6733914
OpenAlexW2969002176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.