ArticleFrontiers in neuroscience2019
Removing Short Wavelengths From Polychromatic White Light Attenuates Circadian Phase Resetting in Rats.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Immediate responses to ambient lightiScience · 2023Article
- Long wavelength light reduces the negative consequences of dim light at night.Neurobiology of disease · 2023Article
- Blue light insertion at night is involved in sleep and arousal-promoting response delays and depressive-like emotion in mice.Bioscience reports · 2021Article
- Circadian Potency Spectrum with Extended Exposure to Polychromatic White LED Light under Workplace Conditions.Journal of biological rhythms · 2020Article
- Neuronal Responses to Short Wavelength Light Deficiency in the Rat Subcortical Visual System.Frontiers in neuroscience · 2020Article
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visible light is the principal stimulus for resetting the mammalian central circadian pacemaker. Circadian phase resetting is most sensitive to short-wavelength (blue) visible light. We examined the effects of removing short-wavelengths < 500 nm from polychromatic white light using optical filters on circadian phase resetting in rats. Under high irradiance conditions, both long- (7 h) and short- (1 h) duration short-wavelength filtered (< 500 nm) light exposure attenuated phase-delay shifts in locomotor activity rhythms by (∼40-50%) as compared to unfiltered light exposure. However, there was no attenuation in phase resetting under low irradiance conditions. Additionally, the reduction in phase-delay shifts corresponded to regionally specific attenuation in molecular markers of pacemaker activation in response to light exposure, including c-FOS, Per1 and Per2. These results demonstrate that removing short-wavelengths from polychromatic white light can attenuate circadian phase resetting in an irradiance dependent manner. These results have important implications for designing and optimizing lighting interventions to enhance circadian adaptation.
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Registered trials
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