ReviewFrontiers in neuroscience2019
Vagus Nerve Stimulation in Rodent Models: An Overview of Technical Considerations.
Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 76 citations in OpenAlex.
- Long-term vagus nerve stimulation synergized with rapamycin elicits neuroimmune modulation to prolong skin allograft survival.iScience · 2026Article
- Computational modeling of human vagus nerve stimulation with three-dimensional fascicular morphology.APL bioengineering · 2026Article
- Water-triggered self-wrapping and immobilization of an all-organic hydrogel-based cuff electrode.Materials today. Bio · 2025Article
- A closed loop fully automated wireless vagus nerve stimulation system.Scientific reports · 2025Article
- Overcoming failure: improving acceptance and success of implanted neural interfaces.Bioelectronic medicine · 2025Review
- Ascending Vagal Sensory and Central Noradrenergic Pathways Modulate Retrieval of Passive Avoidance Memory in Male Rats.Journal of neuroscience research · 2024Article
- Highly-stable, injectable, conductive hydrogel for chronic neuromodulation.Nature communications · 2024Article
- Electrical stimulation of the vagus nerve ameliorates inflammation and disease activity in a rat EAE model of multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- An ascending vagal sensory-central noradrenergic pathway modulates retrieval of passive avoidance memory.bioRxiv : the preprint server for biology · 2024Article
- The immunomodulatory effect of oral NaHCOJournal of neuroinflammation · 2024Article
- Neuroimmune Modulation Through Vagus Nerve Stimulation Reduces Inflammatory Activity in Crohn's Disease Patients: A Prospective Open-label Study.Journal of Crohn's & colitis · 2023Article
- Effect of Vagus Nerve Stimulation on the GASH/Sal Audiogenic-Seizure-Prone Hamster.International journal of molecular sciences · 2023Article
- Electrical stimulation methods and protocols for the treatment of traumatic brain injury: a critical review of preclinical research.Journal of neuroengineering and rehabilitation · 2023Review
- Noninvasive ultrasound stimulation to treat myocarditis through splenic neuro-immune regulation.Journal of neuroinflammation · 2023Article
- Flexible IrOActa biomaterialia · 2023Article
- Bioelectronic medicine for restoring autonomic balance in autoimmune diseases.Gut microbiota and integrative wellness · 2023Article
- Neuromodulation as a Potential Disease-Modifying Therapy for Osteoarthritis.Current rheumatology reports · 2023Review
- An affordable implantable vagus nerve stimulator system for use in animal research.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Article
- Selective Neuromodulation of the Vagus Nerve.Frontiers in neuroscience · 2021Review
- Improved Functional Outcome After Peripheral Nerve Stimulation of the Impaired Forelimb Post-stroke.Frontiers in neurology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last several decades, vagus nerve stimulation (VNS) has evolved from a treatment for select neuropsychiatric disorders to one that holds promise in treating numerous inflammatory conditions. Growing interest has focused on the use of VNS for other indications, such as heart failure, rheumatoid arthritis, inflammatory bowel disease, ischemic stroke, and traumatic brain injury. As pre-clinical research often guides expansion into new clinical avenues, animal models of VNS have also increased in recent years. To advance this promising treatment, however, there are a number of experimental parameters that must be considered when planning a study, such as physiology of the vagus nerve, electrical stimulation parameters, electrode design, stimulation equipment, and microsurgical technique. In this review, we discuss these important considerations and how a combination of clinically relevant stimulation parameters can be used to achieve beneficial therapeutic results in pre-clinical studies of sub-acute to chronic VNS, and provide a practical guide for performing this work in rodent models. Finally, by integrating clinical and pre-clinical research, we present indeterminate issues as opportunities for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.