Evidence map›Paper›PMID 31551654›Full record

ArticlePatient preference and adherence2019

A cultural adaptation and validation study of a self-report measure of the extent of and reasons for medication nonadherence among patients with diabetes in Singapore.

Yuan Wei Liau, Celine Cheow, Kenneth Tin Yau Leung, Hejing Tan, Suat Fern Low, Hua Heng McVin Cheen, Woan Chyi Lim, Li Ling Tan, Joyce Zhen Yin Tan, Eng Sing Lee and 9 more

Open access · goldAbstract read
In one paragraph

Article in Patient preference and adherence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 2 countries.

Yuan Wei LiauDepartment of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
Celine CheowDepartment of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
Kenneth Tin Yau LeungDepartment of Pharmacy, Khoo Teck Puat Hospital, Singapore, Singapore.
Hejing TanDepartment of Pharmacy, Woodlands Health Campus, Singapore, Singapore.
Suat Fern LowDepartment of Pharmacy, Yishun Community Hospital, Singapore, Singapore.
Hua Heng McVin CheenDepartment of Pharmacy, Singapore General Hospital, Singapore, Singapore.
Woan Chyi LimDepartment of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore.
Li Ling TanDepartment of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore.
Joyce Zhen Yin TanDepartment of Pharmacy, Admiralty Medical Centre, Singapore, Singapore.
Eng Sing LeeClinical Research Unit, Family Medicine Development Division, National Healthcare Group Polyclinics, Singapore, Singapore.
Sandra Jialun XuDepartment of Pharmacy, National Healthcare Group Polyclinics (Hougang), Singapore, Singapore.
Corrinne Yong Koon TanPharmacy Transformation Office, National Healthcare Group Pharmacy, Singapore, Singapore.
Jie Wen PhangDepartment of Pharmacy, Ng Teng Fong General Hospital, Singapore, Singapore.
Jie Kie PhangDepartment of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore.
Miao Hui LamDepartment of Pharmacy, Khoo Teck Puat Hospital, Singapore, Singapore.
Dan V BlalockCenter of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham Veterans Affairs Health Care System, Durham, NC, USA.
Corrine I VoilsDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Wisconsin, WI, USA.
Kai Zhen YapDepartment of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
Yu Heng KwanDepartment of Pharmacy, Khoo Teck Puat Hospital, Singapore, Singapore.
Khoo Teck Puat Hospital · SGNational University of Singapore · SGSingapore General Hospital · SGTan Tock Seng Hospital · SGDuke University · USSingHealth Polyclinics · SGUniversity of Wisconsin–Madison · USWoodlands Health Campus · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis self-report measure is a new instrument to measure the extent of and reasons for medication adherence separately. However, few studies have assessed its psychometric properties in diabetic patients and also in Asian populations.

objectivesTo validate this self-report measure in diabetic patients in Singapore.

methodsWe collected data prospectively using a questionnaire among 393 diabetic patients from hospitals in Singapore from July 2018 to January 2019. Using the COnsensus-based Standards for the selection of health Measurement INstruments framework, we assessed face validity, internal consistency, test-retest reliability, structural validity, and measurement error. We tested four a priori hypotheses on correlation of extent score with patient-reported outcome measures to assess construct validity. We examined cross-cultural validity via measurement invariance across gender, age groups, and languages.

resultsWe performed cognitive interviews with 30 consenting English-literate, Chinese-literate, and Malay-literate (10 patients per language) diabetic patients (age range 48-76 years, 53% male, disease duration range 1-30 years) and face validity was supported. Among 393 patients (mean age: 59.4±12.2 years, 50.9% female, 52.4% Chinese), we showed moderate internal consistency (Cronbach's alpha =0.67) and test-retest reliability (intra-class coefficient=0.56 [95% CI 0.37-0.70]). We calculated smallest detectable change as 0.80. We established construct validity by meeting all four hypotheses. We showed structural validity as confirmatory factor analysis confirmed a one-factor model, with excellent fit statistics (Comparative Fit Index=1.0; Tucker-Lewis Index=1.0; Root Mean Square Error of Approximation<0.001; Standardized Root Mean Residuals<0.001). Analysis of cross-cultural validity supported configural invariance model but not metric invariance and scalar invariance model. Caution must be taken against directly comparing extent scores across gender, age groups, and languages.

conclusionThis self-report measure is valid and reliable in measuring medication adherence in diabetic patients in Singapore.

Indexed as

adherencediabetespatient-reported outcomepsychometricquality of lifeSingapore

Identifiers

PMID31551654
PMCPMC6677377
OpenAlexW2964881798

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.