Evidence map›Paper›PMID 31551632›Full record

ArticleBulletin of the World Health Organization2019

Access to insulin: applying the concept of security of supply to medicines.

David Beran, Zafar Mirza, Jicui Dong

Open access · diamondAbstract read
In one paragraph

Article in Bulletin of the World Health Organization, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Barriers to WHO prequalification of similar biotherapeutic insulin.Bulletin of the World Health Organization · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Diabetic ketoacidosis.Nature reviews. Disease primers · 2020
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David BeranDivision of Tropical and Humanitarian Medicine, University of Geneva, Rue Gabrielle-Perret-Gentil 6, CH-1211 Geneva 14, Switzerland.
Zafar MirzaDepartment of Health System Development, World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt.
Jicui DongDepartment of Essential Medicines and Health Products, World Health Organization, Geneva, Switzerland.
World Health Organization · CH

Funding

World Health Organization 001
6 · The paper itself

Abstract

Security of supply of medicines is fundamental to ensure health for all. Furthermore, improving access to medicines is included in sustainable development goal 3. However, the concept of security of supply has mostly been applied to food, water and energy. Diversity of supply, vulnerability to disruption, expenditure, infrastructure, stability of exporting countries, ownership of production, price stability, access and equity, affordability, intellectual property, safety and reliability of supply, and countries' capacity to adapt to market changes are all elements of security of supply. Based on these elements, we assessed security of supply for insulin, since access to insulin is a global problem. We found that three multinational companies, in Denmark, France and Germany, control 99% of the value of the global insulin market. Prices and affordability of insulin and access to it vary considerably between countries. Some countries are vulnerable to insulin shortage because they import insulin from only one source. Many countries spend large amounts of money on insulin and costs are increasing. Some countries lack an adequate infrastructure for procurement, supply chain management and distribution of insulin. Applying the security of supply concept to insulin showed that diversification of suppliers needs to be fostered. Global health actors should adopt a security of supply approach to identify medicines that are susceptible to supply issues and address this concern by strategic promotion of local production, strengthening regulatory harmonization, and adding local products to the World Health Organization's programme on prequalification of medicines.

Indexed as

CommerceDeveloping CountriesDiabetes MellitusDrugs, EssentialEuropeHealth Services AccessibilityHumansInsulinDrugs, EssentialInsulin

Identifiers

PMID31551632
PMCPMC6747032
OpenAlexW2943291926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.