ReviewNature neuroscience2019
Neuromodulation in circuits of aversive emotional learning.
Review in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 77 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed.
- Alpha-2 Adrenoreceptor Antagonist Yohimbine Potentiates Consolidation of Conditioned Fear.The international journal of neuropsychopharmacology · 2022Trial
- A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A ventral hippocampus-basolateral amygdala circuit regulates the unconditioned stimulus retrieval-induced reconsolidation of remote fear memory.Journal of advanced research · 2026Article
- A dual-pathway dysregulation in prefrontal-habenular circuits mediates stress susceptibility.Nature communications · 2026Article
- Basolateral amygdala dopamine transmits emotional salience.Nature communications · 2026Article
- A positive feedback loop between sensory and octopaminergic neurons underlies nociceptive plasticity in Drosophila larvae.PLoS genetics · 2026Article
- Article
- Neural correlates of human fear conditioning and sources of variability in 2199 individuals.Nature communications · 2025Article
- Bidirectional emotional regulation through prefrontal innervation of the locus coeruleus.Molecular psychiatry · 2025Article
- The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input.PLoS biology · 2025Article
- Whole-brain mapping of basal forebrain cholinergic neurons reveals a long-range reciprocal input-output loop between distinct subtypes.Science advances · 2025Article
- Infralimbic Projections to the Substantia Innominata-Ventral Pallidum Constrain Defensive Behavior during Extinction Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus.bioRxiv : the preprint server for biology · 2025Article
- Cholinergic signaling to CA1 astrocytes controls fear extinction.Science advances · 2025Article
- Dopamine prediction error signaling in a unique nigrostriatal circuit is critical for associative fear learning.Nature communications · 2025Article
- The lateralized LC-NAergic system distinguishes vicarious versus direct fear in mice.Nature communications · 2025Article
- Amygdala intercalated cells form an evolutionarily conserved system orchestrating brain networks.Nature neuroscience · 2025Review
- Anticipatory emotions and academic performance: The role of boredom in a preservice teachers' lab experience.Heliyon · 2025Article
- On the genesis and unique functions of zinc neuromodulation.Journal of neurophysiology · 2024Review
- Neuromodulator and neuropeptide sensors and probes for precise circuit interrogation in vivo.Science (New York, N.Y.) · 2024Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
Emotional learning and memory are functionally and dysfunctionally regulated by the neuromodulatory state of the brain. While the role of excitatory and inhibitory neural circuits mediating emotional learning and its control have been the focus of much research, we are only now beginning to understand the more diffuse role of neuromodulation in these processes. Recent experimental studies of the acetylcholine, noradrenaline and dopamine systems in fear learning and extinction of fear responding provide surprising answers to key questions in neuromodulation. One area of research has revealed how modular organization, coupled with context-dependent coding modes, allows for flexible brain-wide or targeted neuromodulation. Other work has shown how these neuromodulators act in downstream targets to enhance signal-to-noise ratios and gain, as well as to bind distributed circuits through neuronal oscillations. These studies elucidate how different neuromodulatory systems regulate aversive emotional processing and reveal fundamental principles of neuromodulatory function.
Indexed as
Identifiers
31551602What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.