ArticleNature neuroscience2019
Layer-dependent activity in human prefrontal cortex during working memory.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.
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Who cites it
122 citing papers in PubMed.
- [Dynamic alterations in regional brain activity associated with bipolar disorder and smoking status].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- A large-scale heterogeneous 3D magnetic resonance brain imaging dataset for self-supervised learning.Scientific data · 2026Article
- Resolving mesoscale brainstem-prefrontal-striatal pathways underlying decisions upon salient events using submillimeter-resolution fMRI.Nature communications · 2026Article
- Bridging the gap with invasive imaging: promises and challenges of a new generation of ultrahigh resolution fMRI.bioRxiv : the preprint server for biology · 2026Article
- Impact of thermal and physiological denoising on laminar functional connectivity.Scientific reports · 2026Article
- Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortex.Cell genomics · 2026Article
- Advancing whole-brain BOLD functional MRI in humans at 10.5 T with motion-robust 3D echo-planar imaging, parallel transmission, and high-density radiofrequency receive coils.Magnetic resonance in medicine · 2026Article
- Task demand modulates somatosensory-frontoparietal networks during delay and retrieval periods in tactile working memory.Communications biology · 2026Article
- Aging-related Transcriptomic Changes with Spatial Resolution in the Human Prefrontal Cortex.bioRxiv : the preprint server for biology · 2026Article
- Article
- Ultra-high field brain MRI for functional neurological disorder: opportunities and challenges.NeuroImage. Clinical · 2026Review
- Prefrontal spine loss in neuropsychiatric disorders: circuit consequences for cognition.Frontiers in psychiatry · 2026Review
- Cross-spatial scale processing of hierarchical auditory sequences in human brains revealed using 7 T magnetic resonance imaging.Nature communications · 2025Article
- The superficial layers of the primary visual cortex create a saliency map that feeds forward to the parietal cortex.PLoS biology · 2025Article
- SuperGLUE facilitates an explainable training framework for multi-modal data analysis.Cell reports methods · 2025Article
- Preparatory attentional templates in prefrontal and sensory cortex encode target-associated information.eLife · 2025Article
- Astrocytic dopamine D1 receptor modulates glutamatergic transmission and synaptic plasticity in the prefrontal cortex through d-serine.Acta pharmaceutica Sinica. B · 2025Article
- Blood volume sensitive laminar fMRI with VASO in human hippocampus: Capabilities and biophysical challenges at clinical 7T scanners.bioRxiv : the preprint server for biology · 2025Article
- Recurrence affects the geometry of visual representations across the ventral visual stream in the human brain.PLoS biology · 2025Article
62 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Working memory involves storing and/or manipulating previously encoded information over a short-term delay period, which is typically followed by a behavioral response based on the remembered information. Although working memory tasks often engage dorsolateral prefrontal cortex, few studies have investigated whether their subprocesses are localized to different cortical depths in this region, and none have done so in humans. Here we use high-resolution functional MRI to interrogate the layer specificity of neural activity during different periods of a delayed-response task in dorsolateral prefrontal cortex. We detect activity time courses that follow the hypothesized patterns: namely, superficial layers are preferentially active during the delay period, specifically in trials requiring manipulation (rather than mere maintenance) of information held in working memory, and deeper layers are preferentially active during the response. Results demonstrate that layer-specific functional MRI can be used in higher-order brain regions to noninvasively map cognitive processing in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.