ArticleScientific reports2019
Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses: a feasibility study on human mastectomies.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Radiomic Characterization of Breast Tissue from Breast CT Images Obtained with Synchrotron Beams.Tomography (Ann Arbor, Mich.) · 2026Article
- Comparison of three reconstruction algorithms for low-dose phase-contrast computed tomography of the breast with synchrotron radiation.Medical physics · 2025Article
- Grating-based phase-contrast computed tomography for breast tissue at an inverse compton source.Scientific reports · 2024Article
- Dedicated breast CT: state of the art-Part II. Clinical application and future outlook.European radiology · 2022Review
- A phase sensitive x-ray breast tomosynthesis system: Preliminary patient images with cancer lesions.Physics in medicine and biology · 2021Article
- Development and preclinical evaluation of a patient-specific high energy x-ray phase sensitive breast tomosynthesis system.Medical physics · 2021Article
- Dose and spatial resolution analysis of grating-based phase-contrast mammography using an inverse Compton x-ray source.Journal of medical imaging (Bellingham, Wash.) · 2020Article
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19 authors.
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Abstract
In this study we demonstrate the first direct comparison between synchrotron x-ray propagation-based CT (PB-CT) and cone-beam breast-CT (CB-CT) on human mastectomy specimens (N = 12) including different benign and malignant lesions. The image quality and diagnostic power of the obtained data sets were compared and judged by two independent expert radiologists. Two cases are presented in detail in this paper including a comparison with the corresponding histological evaluation. Results indicate that with PB-CT it is possible to increase the level of contrast-to-noise ratio (CNR) keeping the same level of dose used for the CB-CT or achieve the same level of CNR reached by CB-CT at a lower level of dose. In other words, PB-CT can achieve a higher diagnostic potential compared to the commercial breast-CT system while also delivering a considerably lower mean glandular dose. Therefore, we believe that PB-CT technique, if translated to a clinical setting, could have a significant impact in improving breast cancer diagnosis.
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