ArticleNature communications2019
Genetic architecture of human plasma lipidome and its link to cardiovascular disease.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 5 pooled it
15.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
114 citing papers in PubMed, 5 syntheses or guidelines pooled it, 192 citations in OpenAlex.
- Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.Nature communications · 2022Pooled it
- Large-scale Integrated Analysis of Genetics and Metabolomic Data Reveals Potential Links Between Lipids and Colorectal Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis.Scientific reports · 2021Pooled it
- Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.Nature communications · 2021Pooled it
- Genomic study of maternal lipid traits in early pregnancy concurs with four known adult lipid loci.Journal of clinical lipidologyPooled it
- Circulatory lipid signature in response to short-term testosterone gel treatment of healthy young females.Scientific reports · 2025Trial
- Association of Physical Activity With Bioactive Lipids and Cardiovascular Events.Circulation research · 2022Trial
- Sphingolipids and Atherosclerosis.Current atherosclerosis reports · 2026Review
- In Silico Systems Biology Approach for Prioritization of Candidate Genes Linked to Lipid Metabolism in the Context of Cardiovascular Disease Susceptibility in a Serbian Cohort.Current issues in molecular biology · 2026Article
- Neurobehavioural genes exert indirect genetic effects on blood lipid profiles through behavioural traits.Communications biology · 2026Article
- Unveiling novel drug targets for atherosclerosis: A Mendelian randomization analysis.Medicine · 2026Article
- Population-based genome-wide association study of plasma complex lipid species.Nature communications · 2026Article
- Lipidomic analyses of large cohort studies define the role of lipid metabolism in bridging diet and cardio-metabolic health.Nature communications · 2026Article
- Genetic regulation of fatty acid content in adipose tissue.American journal of human genetics · 2026Article
- Synergistic effects of genetic susceptibility and air pollution on cardiovascular disease.American journal of preventive cardiology · 2026Article
- Blood lipidome profiling reveals potential biomarkers linked to health and carcass quality traits in pigs.Genetics, selection, evolution : GSE · 2026Article
- Linking the plasma proteome to genetics in individuals from continental Africa provides insights into type 2 diabetes pathogenesis.Nature genetics · 2026Article
- HUBMet: an integrative database and analytical platform for human blood metabolites and metabolite-protein associations.Genome biology · 2025Article
- Review
- Utilizing multimodal artificial intelligence to advance cardiovascular diseases.Precision clinical medicine · 2025Review
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 20 institutions in 7 countries.
Rubina TabassumInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
Joel T RämöInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
Pietari RipattiInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-6530-3243
Jukka T KoskelaInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-0154-7222
Mitja KurkiInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
Juha KarjalainenInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
Priit PaltaInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-9320-7008
Shabbeer HassanInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
Javier Nunez-FontarnauInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
Tuomo T J KiiskinenInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
Sanni SöderlundResearch Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland.
Niina MatikainenResearch Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0003-0041-1240
Mathias J GerlLipotype GmbH, Dresden, Germany.ORCID http://orcid.org/0000-0002-8074-7221
Michal A SurmaLipotype GmbH, Dresden, Germany.ORCID http://orcid.org/0000-0001-7833-2214
Christian KloseLipotype GmbH, Dresden, Germany.
Nathan O StitzielCardiovascular Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Hannele LaivuoriInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-3212-7826
Aki S HavulinnaInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
Susan K ServiceCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, Finland.ORCID http://orcid.org/0000-0001-7563-5324
Matti PirinenInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-1664-1350
FinnGen Project
Matti JauhiainenNational Institute for Health and Welfare, Helsinki, Finland.
Mark J DalyInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
Nelson B FreimerCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3586-6587
Aarno PalotieInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.
Marja-Riitta TaskinenResearch Programs Unit, Diabetes & Obesity, University of Helsinki and Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland.
Kai SimonsLipotype GmbH, Dresden, Germany.
Samuli RipattiInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland. samuli.ripatti@helsinki.fi.
University of Helsinki · FIHospital District of Helsinki and Uusimaa · FIFinnish Institute for Health and Welfare · FIAbbVie (United States) · USPfizer (United States) · USGlaxoSmithKline (United Kingdom) · GBMerck & Co., Inc., Rahway, NJ, USA (United States) · USNorthern Ostrobothnia Hospital District · FIVarsinais-Suomen Sairaanhoitopiiri · FIBorealis (Finland) · FIPirkanmaa Hospital District · FISanofi (France) · FRBroad Institute · USBiogen (United States) · USTampere University · FICentral Finland Health Care District · FIAstraZeneca (United Kingdom) · GBFinnish Red Cross · FIUniversity of Turku · FIBusiness Finland
Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MGenomic and Metabolomic Profiling of Finnish Familial Dyslipidemia FamiliesR01HL113315 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B., PALOTIE, AARNO · 2012 to 2016
$3.4MANGPTL3 DEFICIENCY AND ATHEROSCLEROSIS IN HUMANSR01HL131961 · NHLBI · WASHINGTON UNIVERSITY · PI STITZIEL, NATHAN OLIVER · 2016 to 2020
$3.2MNHLBI NIH HHS R01 HL113315NHLBI NIH HHS R01 HL131961NIDDK NIH HHS P30 DK056341
Abstract
Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10
Indexed as
LipidomicsCardiovascular DiseasesGenome-Wide Association StudyHumansLipidsPlasmaLipids
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.