Evidence map›Paper›PMID 31551408›Full record

ArticleExperimental & molecular medicine2019

Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications.

Yea Seong Ryu, Kyoung Ah Kang, Mei Jing Piao, Mee Jung Ahn, Joo Mi Yi, Guillaume Bossis, Young-Min Hyun, Chang Ook Park, Jin Won Hyun

Open access · goldAbstract read
In one paragraph

Article in Experimental & molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Marnetegragene Autotemcel: First Approval.Molecular diagnosis & therapy · 2026
    Review
  5. Review
  6. Review
  7. Cellular Senescence Triggered by Food and Environmental Genotoxins.International journal of molecular sciences · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Galangin Mitigates PMApplied biochemistry and biotechnology · 2025
    Article
  13. Article
  14. Air Pollution and Skin Diseases.Annals of dermatology · 2025
    Review
  15. Characterization of a NaWorld journal of microbiology & biotechnology · 2025
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Yea Seong Ryu *Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju, 63243, Republic of Korea.
Kyoung Ah Kang *Jeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju, 63243, Republic of Korea.
Mei Jing PiaoJeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju, 63243, Republic of Korea.
Mee Jung AhnLaboratory of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University, Jeju, 63243, Republic of Korea.
Joo Mi YiDepartment of Microbiology and Immunology, Inje University College of Medicine, Busan, 47392, Republic of Korea.
Guillaume BossisInstitut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France.ORCID http://orcid.org/0000-0002-3349-8250
Young-Min HyunDepartment of Anatomy, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.ORCID http://orcid.org/0000-0002-0567-2039
Chang Ook ParkDepartment of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Jin Won HyunJeju National University School of Medicine and Jeju Research Center for Natural Medicine, Jeju, 63243, Republic of Korea. jinwonh@jejunu.ac.kr.
Jeju National University · KRYonsei University · KRCentre National de la Recherche Scientifique · FRInje University · KRJeju National University Hospital · KR

Funding

National Research Foundation of Korea (NRF) 2017R1A4A1014512
6 · The paper itself

Abstract

Ambient air particulate matter (PM) induces senescence in human skin cells. However, the underlying mechanisms remain largely unknown. We investigated how epigenetic regulatory mechanisms participate in cellular senescence induced by PM with a diameter <2.5 (PM

Indexed as

Epigenesis, GeneticAnimalsCell ProliferationCellular SenescenceCyclin-Dependent Kinase Inhibitor p16DNA-Binding ProteinsDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3BEnhancer of Zeste Homolog 2 ProteinHistone-Lysine N-MethyltransferaseHumansKeratinocytesMiceMyeloid-Lymphoid Leukemia ProteinCyclin-Dependent Kinase Inhibitor p16DNA-Binding ProteinsDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseHistone-Lysine N-MethyltransferaseKmt2a protein, mouseMyeloid-Lymphoid Leukemia ProteinParticulate MatterProto-Oncogene ProteinsReactive Oxygen SpeciesReceptors, Aryl HydrocarbonTET1 protein, mouse

Identifiers

PMID31551408
PMCPMC6802667
OpenAlexW2976086758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.