Evidence map›Paper›PMID 31551328›Full record

ArticlemBio2019

Role of Dietary Flavonoid Compounds in Driving Patterns of Microbial Community Assembly.

Kerry L Ivey, Andrew T Chan, Jacques Izard, Aedin Cassidy, Geraint B Rogers, Eric B Rimm

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
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  3. Article
  4. Pharmaceutics · 2025
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  15. Review
  16. Polyphenol Utilization Proteins in the Human Gut Microbiome.Applied and environmental microbiology · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 3 countries.

Kerry L IveyDepartment of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA kivey@hsph.harvard.edu.
Andrew T Chan *Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jacques Izard *Food Science and Technology Department, University of Nebraska, Lincoln, Nebraska, USA.
Aedin CassidyInstitute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland.
Geraint B Rogers *Infection and Immunity Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Eric B Rimm *Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Brigham and Women's Hospital · USFlinders University · AUHarvard University · USQueen's University Belfast · GBSouth Australian Health and Medical Research Institute · AUUniversity of Nebraska–Lincoln · US

Funding

Dietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
Validity of Diet and Activity Measures in MenU01CA152904 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI RIMM, ERIC B, STAMPFER, MEIR · 2010 to 2013
$7.2M
Characterizing the gut microbial ecosystem for diagnosis and therapy in IBDU54DE023798 · NIDCR · BROAD INSTITUTE, INC. · PI HUTTENHOWER, CURTIS, XAVIER, RAMNIK J · 2013 to 2014
$3.0M
Dietary sulfur, the gut microbiome, and colorectal cancerR01CA202704 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T, GARRETT, WENDY S. · 2016 to 2020
$2.8M
Mentored Patient-Oriented Research in Digestive DiseasesK24DK098311 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T · 2013 to 2017
$930k
NCI NIH HHS R01 CA202704NCI NIH HHS U01 CA152904NCI NIH HHS UM1 CA167552NHLBI NIH HHS R01 HL035464NIDCR NIH HHS U54 DE023798NIDDK NIH HHS K24 DK098311
6 · The paper itself

Abstract

Flavonoids are a group of polyphenolic dietary compounds found in many different plant-based foods. There is increasing evidence that higher flavonoid intake may be causally linked to a reduced risk of cardiovascular disease and other chronic diseases. The bioactivity and bioavailability of many dietary flavonoids can be influenced by gastrointestinal microbiome metabolism. However, the role that habitual flavonoid intake plays in shaping the human gut microbiome is poorly understood. We describe an application of an ecosystem-based analytic approach to nutritional, microbiome, and questionnaire data from a cohort of more than 240 generally healthy adult males to assess the role of dietary flavonoid compounds in driving patterns of microbial community assembly. We identified six subclass-specific microbial communities (SMCs) uniquely and independently associated with intakes of the six flavonoid subclasses.

Indexed as

Dietary SupplementsAdultAgedAged, 80 and overFlavonoidsGastrointestinal MicrobiomeHumansMaleMicrobiotaMiddle AgedSurveys and QuestionnairesUnited StatesFlavonoidsdietflavonoidmicrobiome

Identifiers

PMID31551328
PMCPMC6759757
OpenAlexW2976472408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.