ArticleProceedings. Biological sciences2019
Allometry of mitochondrial efficiency is set by metabolic intensity.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Convergent elevation of mitochondrial proton leakage improves thermogenesis in honeybees.Molecular biology and evolution · 2026Article
- Developmental bioenergetics: a comparative perspective on mitochondrial efficiency in paediatric physiology.The Journal of physiology · 2026Article
- Acute and prolonged effects of anti-malarial drugs on mitochondrial respiration in atrial cardiomyocytes for cardiac safety evaluation.PloS one · 2026Article
- The energy resistance principle.Cell metabolism · 2025Review
- Inter-Caste Comparison Reveals a Unique Bioenergetic Signature in Long-Lived Ant Queens.Molecular ecology · 2025Article
- Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia.The Journal of physiology · 2024Article
- Autofluorescence imaging of endogenous metabolic cofactors in response to cytokine stimulation of classically activated macrophages.Cancer & metabolism · 2023Article
- Modulators reducing the efficiency of oxidative ATP synthesis in mitochondria: protonophore uncouplers, cyclic redox agents, and decouplers.Biophysical reviews · 2023Review
- White Paper: An Integrated Perspective on the Causes of Hypometric Metabolic Scaling in Animals.Integrative and comparative biology · 2022Article
- Mice selected for a high basal metabolic rate evolved larger guts but not more efficient mitochondria.Proceedings. Biological sciences · 2022Article
- Coevolution of body size and metabolic rate in vertebrates: a life-history perspective.Biological reviews of the Cambridge Philosophical Society · 2020Article
- Mitochondrial physiology varies with parity and body mass in the laboratory mouse (Mus musculus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Allometry of mitochondrial efficiency is set by metabolic intensity.Proceedings. Biological sciences · 2019Article
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4 authors.
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Abstract
Metabolic activity sets the rates of individual resource uptake from the environment and resource allocations. For this reason, the relationship with body size has been heavily documented from ecosystems to cells. Until now, most of the studies used the fluxes of oxygen as a proxy of energy output without knowledge of the efficiency of biological systems to convert oxygen into ATP. The aim of this study was to examine the allometry of coupling efficiency (ATP/O) of skeletal muscle mitochondria isolated from 12 mammal species ranging from 6 g to 550 kg. Mitochondrial efficiencies were measured at different steady states of phosphorylation. The efficiencies increased sharply at higher metabolic rates. We have shown that body mass dependence of mitochondrial efficiency depends on metabolic intensity in skeletal muscles of mammals. Mitochondrial efficiency positively depends on body mass when mitochondria are close to the basal metabolic rate; however, the efficiency is independent of body mass at the maximum metabolic rate. As a result, it follows that large mammals exhibit a faster dynamic increase in ATP/O than small species when mitochondria shift from basal to maximal activities. Finally, the invariant value of maximal coupling efficiency across mammal species could partly explain why scaling exponent values are very close to 1 at maximal metabolic rates.
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