Evidence map›Paper›PMID 31550881›Full record

ArticleACS chemical biology2019

Extending the Detection Limit in Fragment Screening of Proteins Using Reverse Micelle Encapsulation.

Brian Fuglestad, Nicole E Kerstetter, Sabrina Bédard, A Joshua Wand

Abstract read
In one paragraph

Article in ACS chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Harmonizing Peak Matching between Multidimensional NMR Spectra.Journal of chemical information and modeling · 2026
    Article
  2. Harmonizing Peak Matching Between Multidimensional NMR Spectra.bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brian FuglestadJohnson Research Foundation and Department of Biochemistry and Biophysics , University of Pennsylvania, Perelman School of Medicine , Philadelphia , Pennsylvania 19104 , United States.
Nicole E KerstetterGraduate Group in Biochemistry and Molecular Biophysics , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.ORCID 0000-0003-3386-0384
Sabrina BédardJohnson Research Foundation and Department of Biochemistry and Biophysics , University of Pennsylvania, Perelman School of Medicine , Philadelphia , Pennsylvania 19104 , United States.
A Joshua WandJohnson Research Foundation and Department of Biochemistry and Biophysics , University of Pennsylvania, Perelman School of Medicine , Philadelphia , Pennsylvania 19104 , United States.ORCID 0000-0001-8341-0782

Funding

STRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008275 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WAND, A. JOSHUA · 1988 to 2018
$6.0M
Nanoscale Encapsulation for Fragment Based Drug DiscoveryR21CA206958 · NCI · UNIVERSITY OF PENNSYLVANIA · PI WAND, A. JOSHUA · 2016 to 2017
$385k
NCI NIH HHS R21 CA206958NIGMS NIH HHS T32 GM008275
6 · The paper itself

Abstract

Detection of very weak (

Indexed as

MicellesCapsulesDrug DiscoveryEscherichia coliInterleukin-1betaLigandsLimit of DetectionMagnetic Resonance SpectroscopyMolecular StructureNitrogen IsotopesProtein BindingSmall Molecule LibrariesStructure-Activity RelationshipTetrahydrofolate DehydrogenaseCapsulesInterleukin-1betaLigandsMicellesNitrogen-15Nitrogen IsotopesSmall Molecule LibrariesTetrahydrofolate Dehydrogenase

Identifiers

PMID31550881
PMCPMC7051832

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.