Evidence map›Paper›PMID 31550664›Full record

ArticleRedox biology2020

Gestational oxidative stress protects against adult obesity and insulin resistance.

Lidiya G Dimova, Simone Battista, Torsten Plösch, Rosalie A Kampen, Fan Liu, Rikst Nynke Verkaik-Schakel, Domenico Pratico, Henkjan J Verkade, Uwe J F Tietge

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Lidiya G DimovaDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, the Netherlands.
Simone BattistaDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, the Netherlands.
Torsten PlöschDepartment of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, the Netherlands.
Rosalie A KampenDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, the Netherlands.
Fan LiuDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, the Netherlands; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Alfred Nobels Alle 8, Stockholm, Sweden.
Rikst Nynke Verkaik-SchakelDepartment of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, the Netherlands.
Domenico PraticoAlzheimer's Center at Temple, Lewis Katz School of Medicine, Temple University, 3500 N Broad St, Philadelphia, PA, USA.
Henkjan J VerkadeDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, the Netherlands.
Uwe J F TietgeDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, the Netherlands; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Alfred Nobels Alle 8, Stockholm, Sweden; Clinical Chemistry, Karolinska University Laboratory, Karolinska University Hospital, Stockholm, Sweden. Electronic address: u_tietge@yahoo.com.
University of Groningen · NLUniversity Medical Center Groningen · NLTemple University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy complications such as preeclampsia cause increased fetal oxidative stress and fetal growth restriction, and associate with a higher incidence of adult metabolic syndrome. However, the pathophysiological contribution of oxidative stress per se is experimentally difficult to discern and has not been investigated. This study determined, if increased intrauterine oxidative stress (IUOx) affects adiposity, glucose and cholesterol metabolism in adult Ldlr-/-xSod2+/+ offspring from crossing male Ldlr-/-xSod2+/+ mice with Ldlr-/-xSod2 +/- dams (IUOx) or Ldlr-/-xSod2 +/- males with Ldlr-/-xSod2+/+ dams (control). At 12 weeks of age mice received Western diet for an additional 12 weeks. Adult male IUOx offspring displayed lower body weight and reduced adiposity associated with improved glucose tolerance compared to controls. Reduced weight gain in IUOx was conceivably due to increased energy dissipation in white adipose tissue conveyed by higher expression of Ucp1 and an accompanying decrease in DNA methylation in the Ucp1 enhancer region. Female offspring did not show comparable phenotypes. These results demonstrate that fetal oxidative stress protects against the obesogenic effects of Western diet in adulthood by programming energy dissipation in white adipose tissue at the level of Ucp1.

Indexed as

Insulin ResistanceOxidative StressAdipose TissueAdiposityAnimalsBody CompositionDisease Models, AnimalFemaleFetal Growth RetardationGlucoseLipid MetabolismMaleMaternal ExposureMiceMice, TransgenicObesityGlucosePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseSuperoxide DismutaseSuperoxide Dismutase 2AdiposityEpigeneticsFetal oxidative stressMetabolic programmingMethylationMitohormesis

Identifiers

PMID31550664
PMCPMC6812053
OpenAlexW2973912712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.