ArticleDevelopmental biology2020
Hedgehog signaling promotes lipolysis in adipose tissue through directly regulating Bmm/ATGL lipase.
Article in Developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Systemic Sonic Hedgehog Signaling Links Intestinal Nutrient Sensing With Sex-Specific Type 2 Diabetes Progression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Genome-wide scans for signatures of selection in North African sheep reveals differentially selected regions between fat- and thin-tailed breeds.Animal genetics · 2025Article
- Gut-Brain Dialogues in Fruit Fly (Current drug targets · 2025Review
- Maternal lipid mobilization is essential for embryonic development in the malaria vector Anopheles gambiae.PLoS biology · 2024Article
- Curcumin and Methotrexate: A Promising Combination for Osteosarcoma Treatment via Hedgehog Pathway Inhibition.International journal of molecular sciences · 2024Article
- A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster.Development (Cambridge, England) · 2023Article
- Article
- GPCR in Adipose Tissue Function-Focus on Lipolysis.Biomedicines · 2023Review
- Transcriptome profiling in rumen, reticulum, omasum, and abomasum tissues during the developmental transition of pre-ruminant to the ruminant in yaks.Frontiers in veterinary science · 2023Article
- Hedgehog-mediated gut-taste neuron axis controls sweet perception in Drosophila.Nature communications · 2022Article
- Integrated Analysis of lncRNA and mRNA in Subcutaneous Adipose Tissue of Ningxiang Pig.Biology · 2021Article
- Hedgehog/GLI1 signaling pathway regulates the resistance to cisplatin in human osteosarcoma.Journal of Cancer · 2021Article
- Metabolism and growth adaptation to environmental conditions in Drosophila.Cellular and molecular life sciences : CMLS · 2020Review
- Regulation of Body Size and Growth Control.Genetics · 2020Review
- Physiological and Pathological Regulation of Peripheral Metabolism by Gut-Peptide Hormones inFrontiers in physiology · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Hedgehog (Hh) signaling has been shown to regulate multiple developmental processes, however, it is unclear how it regulates lipid metabolism. Here, we demonstrate that Hh signaling exhibits potent activity in Drosophila fat body, which is induced by both locally expressed and midgut-derived Hh proteins. Inactivation of Hh signaling increases, whereas activation of Hh signaling decreases lipid accumulation. The major lipase Brummer (Bmm) acts downstream of Smoothened (Smo) in Hh signaling to promote lipolysis, therefore, the breakdown of triacylglycerol (TAG). We identify a critical Ci binding site in bmm promoter that is responsible to mediate Bmm expression induced by Hh signaling. Genomic mutation of the Ci binding site significantly reduces the expression of Bmm and dramatically decreases the responsiveness to Ci overexpression. Together, our findings provide a model for lipolysis to be regulated by Hh signaling, raising the possibility for Hh signaling to be involved in lipid metabolic and/or lipid storage diseases.
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Registered trials
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