Transposition: A CRISPR Way to Get Around.

Tatiana Dimitriu, Ben Ashby, Edze R Westra

Open access · bronzeAbstract readComment

In one paragraph

Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

0.3field-weighted citation impact, top 40% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

Genome editing in East African cichlids and tilapias: state-of-the-art and future directions.Open biology · 2023
Review
Digging into the lesser-known aspects of CRISPR biology.International microbiology : the official journal of the Spanish Society for Microbiology · 2021
Review
Unveiling Human Non-Random Genome Editing Mechanisms Activated in Response to Chronic Environmental Changes: I. Where Might These Mechanisms Come from and What Might They Have Led To?Cells · 2020
Review
Jump around: transposons in and out of the laboratory.F1000Research · 2020
Review

4 · The record

Corrections and comments

Comment on
Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration.2019
Comment on
RNA-guided DNA insertion with CRISPR-associated transposases.2019

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Tatiana DimitriuEnvironment and Sustainability Institute, Biosciences, University of Exeter, Cornwall Campus, Penryn, Cornwall TR10 9FE, UK.

Ben AshbyDepartment of Mathematical Sciences, University of Bath, Claverton Down, Bath, Somerset BA2 7AY, UK.

Edze R WestraEnvironment and Sustainability Institute, Biosciences, University of Exeter, Cornwall Campus, Penryn, Cornwall TR10 9FE, UK. Electronic address: E.R.Westra@exeter.ac.uk.

University of Exeter · GBUniversity of Bath · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRISPR-Cas systems provide sequence-specific immunity against selfish genetic elements in prokaryotes. Now, two studies show that transposon-encoded variants can guide sequence-specific transposition. These findings have important practical implications but also raise questions of why and how this strategy would benefit transposons.

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsTransposasesCRISPR-Cas SystemsDNA Transposable ElementsRNADNA Transposable ElementsRNATransposases

Identifiers

PMID31550477

DOI10.1016/j.cub.2019.08.010

OpenAlexW2977282151

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.