Canonical Wnt Signaling Sets the Pace.

C Geoffrey Burns, Caroline E Burns

Abstract readComment

In one paragraph

Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

DNA methylation cooperates with H3K9me2 at HCN4 promoter to regulate the differentiation of bone marrow mesenchymal stem cells into pacemaker-like cells.PloS one · 2023
Article
Advances in 3D bioprinting technology for cardiac tissue engineering and regeneration.Bioactive materials · 2021
Review
5-Azacytidine-Induced Cardiomyocyte Differentiation of Very Small Embryonic-Like Stem Cells.Stem cells international · 2020
Article

4 · The record

Corrections and comments

Comment on
Canonical Wnt5b Signaling Directs Outlying Nkx2.5+ Mesoderm into Pacemaker Cardiomyocytes.2019

5 · Who and what money

Authors and funding

2 authors.

C Geoffrey BurnsDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: geoff.burns@childrens.harvard.edu.

Caroline E BurnsDepartment of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: caroline.burns@childrens.harvard.edu.

Funding

Change of InstitutionR35HL135831 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BURNS, CAROLINE E · 2017 to 2023

$4.2M

Modeling thoracic aortic aneurysm in zebrafishR01HL139806 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BURNS, C. GEOFFREY · 2018 to 2021

$1.7M

NHLBI NIH HHS R01 HL139806NHLBI NIH HHS R35 HL135831

6 · The paper itself

Abstract

In this issue of Developmental Cell, Ren et al. (2019) identify the embryonic origin of cardiac pacemaker cells in zebrafish and implicate Wnt5b in promoting their differentiation. Furthermore, canonical Wnt activation in human stem cell-derived cardiac progenitors produces functional pacemaker cells in vitro, advancing the therapeutic potential of biological pacemakers.

Indexed as

Wnt Signaling PathwayAnimalsCell DifferentiationHumansMesodermMyocytes, CardiacWnt ProteinsWNT5B protein, humanWnt Proteins

Identifiers

PMID31550460

DOI10.1016/j.devcel.2019.09.002

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.