Evidence map›Paper›PMID 31550457›Full record

ArticleNeuropharmacology2020

The critical role of persistent sodium current in hippocampal gamma oscillations.

Young-Jin Kang, Ethan M Clement, Stefan L Sumsky, Yangfei Xiang, In-Hyun Park, Sabato Santaniello, Lazar John Greenfield, Edgar Garcia-Rill, Bret N Smith, Sang-Hun Lee

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Ketamine Reverses Chronic Stress-Induced Behavioral Changes via the Expression of CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Young-Jin KangDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.
Ethan M ClementDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Stefan L SumskyBiomedical Engineering Department, CT Institute for Brain and Cognitive Sciences, University of Connecticut, Storrs, CT 06269, USA.
Yangfei XiangDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine, New Haven, CT 06520, USA.
In-Hyun ParkDepartment of Genetics, Yale Stem Cell Center, Yale Child Study Center, Yale School of Medicine, New Haven, CT 06520, USA.
Sabato SantanielloBiomedical Engineering Department, CT Institute for Brain and Cognitive Sciences, University of Connecticut, Storrs, CT 06269, USA.
Lazar John GreenfieldDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; Department of Neurology, University of Connecticut Health Center, Farmington, CT 06030, USA.
Edgar Garcia-RillCenter for Translational Neuroscience, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Bret N SmithDepartment of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.
Sang-Hun LeeDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA; Center for Translational Neuroscience, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. Electronic address: sanghunlee@uky.edu.
University of Kentucky · USUniversity of Arkansas for Medical Sciences · USUniversity of Connecticut · USYale Cancer Center · USUConn Health · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Telemedicine CoreP30GM110702 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI GARCIA-RILL, EDGAR E. · 2014 to 2018
$6.1M
Contribution of adult neurogenesis to epileptogenesis and recovery after TBIR01NS092552 · NINDS · UNIVERSITY OF KENTUCKY · PI SMITH, BRET N · 2018 to 2022
$2.1M
NCATS NIH HHS UL1 TR001863NIGMS NIH HHS P30 GM110702NINDS NIH HHS R01 NS092552
6 · The paper itself

Abstract

Gamma network oscillations in the brain are fast rhythmic network oscillations in the gamma frequency range (~30-100 Hz), playing key roles in the hippocampus for learning, memory, and spatial processing. There is evidence indicating that GABAergic interneurons, including parvalbumin-expressing basket cells (PVBCs), contribute to cortical gamma oscillations through synaptic interactions with excitatory cells. However, the molecular, cellular, and circuit underpinnings underlying generation and maintenance of cortical gamma oscillations are largely elusive. Recent studies demonstrated that intrinsic and synaptic properties of GABAergic interneurons and excitatory cells are regulated by a slowly inactivating or non-inactivating sodium current (i.e., persistent sodium current, I

Indexed as

AnimalsCA1 Region, HippocampalCalcium-Calmodulin-Dependent Protein Kinase Type 2Excitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGABAergic NeuronsGamma RhythmHippocampusInhibitory Postsynaptic PotentialsInterneuronsMiceOptogeneticsParvalbuminsPatch-Clamp TechniquesPhenytoinPyramidal CellsCalcium-Calmodulin-Dependent Protein Kinase Type 2Excitatory Amino Acid AntagonistsParvalbuminsPhenytoinRiluzoleSodiumVoltage-Gated Sodium Channel BlockersAntiepileptic drugsCognitive impairmentOptogeneticsParvalbumin-expressing interneuronsPyramidal-interneuron network gamma (PING)

Identifiers

PMID31550457
PMCPMC6952064
OpenAlexW2974202607

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.