Evidence map›Paper›PMID 31550409›Full record

ReviewAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

Non-HLA donor-recipient mismatches in kidney transplantation-A stone left unturned.

Samira Farouk, Zhongyang Zhang, Madhav C Menon

Abstract readReview
In one paragraph

Review in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Samira FaroukDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0001-5598-5925
Zhongyang ZhangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Madhav C MenonDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-9567-4299

Funding

Noninvasive Markers and Transplant Outcome in HumansU01AI063594 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEEGER, PETER SCOTT · 2004 to 2022
$66.5M
Genomics of Chronic Renal Allograft RejectionU01AI070107 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MURPHY, BARBARA T. · 2006 to 2012
$9.4M
Dichotomous roles of Shroom3 in Tubular cells and Podocytes in native and allograft kidneysR01DK122164 · NIDDK · YALE UNIVERSITY · PI Madhav C Menon · 2019 to 2026
$2.7M
Clinical Trials in Organ Transplantation-19NIAID NIH HHS U01 AI063594NIAID NIH HHS U01 AI070107NIDDK NIH HHS R01 DK122164
6 · The paper itself

Abstract

In kidney transplantation, short-term allograft survival has improved due to improvements in acute rejection episodes without corresponding improvements in long-term survival. Although current organ allocation algorithms take into account human leukocyte antigen (HLA) matching to reduce antidonor alloimmune responses, it is likely that genomic variation at non-HLA loci (ie, non-HLA donor-recipient [D-R] pair mismatches) play a role in the "non-self" responses and ultimately affect long-term allograft survival. Existing data from both animal models and human studies suggest an association between non-HLA D-R mismatches and kidney allograft outcomes. In this minireview, we examine existing and emerging data and discuss putative mechanisms on the role of non-HLA D-R mismatches on long-term allograft outcomes in kidney transplantation.

Indexed as

Graft RejectionGraft SurvivalHistocompatibilityHLA AntigensHumansKidney TransplantationTissue DonorsTransplant RecipientsHLA Antigenseditorialgeneticsgenomicskidney transplantationnephrologypersonal viewpointsciencetranslational research

Identifiers

PMID31550409
PMCPMC7898079

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.