Evidence map›Paper›PMID 31550401›Full record

ArticleJournal of neuroendocrinology2019

Time-of-day-dependent sensitivity of the reproductive axis to RFamide-related peptide-3 inhibition in female Syrian hamsters.

Neta Gotlieb, Cydni N Baker, Jacob Moeller, Lance J Kriegsfeld

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Neta GotliebDepartment of Psychology, University of California, Berkeley, Berkeley, CA, USA.
Cydni N BakerDepartment of Psychology, University of California, Berkeley, Berkeley, CA, USA.
Jacob MoellerDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA.
Lance J KriegsfeldDepartment of Psychology, University of California, Berkeley, Berkeley, CA, USA.
University of California, Berkeley · US

Funding

The role of kisspeptin and RFRP-3 in the neuroendocrine control of female reproductionR01HD050470 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI KRIEGSFELD, LANCE J · 2007 to 2022
$5.0M
NICHD NIH HHS R01 HD050470
6 · The paper itself

Abstract

In spontaneously ovulating rodent species, the timing of the luteinising hormone (LH) surge is controlled by the master circadian pacemaker in the suprachiasmatic nucleus (SCN). The SCN initiates the LH surge via the coordinated control of two opposing neuropeptidergic systems that lie upstream of the gonadotrophin-releasing hormone (GnRH) neuronal system: the stimulatory peptide, kisspeptin, and the inhibitory peptide, RFamide-related peptide-3 (RFRP-3; the mammalian orthologue of avian gonadotrophin-inhibitory hormone [GnIH]). We have previously shown that the GnRH system exhibits time-dependent sensitivity to kisspeptin stimulation, further contributing to the precise timing of the LH surge. To examine whether this time-dependent sensitivity of the GnRH system is unique to kisspeptin or a more common mechanism of regulatory control, we explored daily changes in the response of the GnRH system to RFRP-3 inhibition. Female Syrian hamsters were ovariectomised to eliminate oestradiol (E

Indexed as

AnimalsArcuate Nucleus of HypothalamusCircadian RhythmCricetinaeFemaleGene Expression RegulationGonadotropin-Releasing HormoneGonadotropinsKisspeptinsLuteinizing HormoneMesocricetusNeuropeptidesReproductionSignal TransductionTime FactorsGonadotropin-Releasing HormoneGonadotropinsKisspeptinsLuteinizing HormoneNeuropeptidesRFamide peptidecircadian rhythmsHPGKiss1reproduction

Identifiers

PMID31550401
PMCPMC6991702
OpenAlexW2976602151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.