Evidence map›Paper›PMID 31549965›Full record

ArticleeLife2019

Myogenic vasoconstriction requires G

Ramesh Chennupati, Angela Wirth, Julie Favre, Rui Li, Rémy Bonnavion, Young-June Jin, Astrid Wietelmann, Frank Schweda, Nina Wettschureck, Daniel Henrion and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Pacemaking in the lymphatic system.The Journal of physiology · 2026
    Review
  3. Article
  4. LRRC8A anion channels modulate vascular reactivity via association with myosin phosphatase rho interacting protein.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  5. Vascular mechanotransduction.Physiological reviews · 2023
    Review
  6. Novel Smooth Muscle CaCirculation · 2022
    Article
  7. TRPV1 in arteries enables a rapid myogenic tone.The Journal of physiology · 2022
    Article
  8. Article
  9. Myogenic Vasoconstriction Requires Canonical GJournal of the American Heart Association · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Ramesh ChennupatiDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.ORCID 0000-0002-3994-5285
Angela WirthInstitute of Pharmacology, University of Heidelberg, Heidelberg, Germany.
Julie FavreLaboratoire MITOVASC, UMR CNRS 6015 - INSERM 1083, Université d'Angers, Angers, France.
Rui LiDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Rémy BonnavionDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Young-June JinDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Astrid WietelmannScientific Service Group Nuclear Magnetic Resonance Imaging, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Frank SchwedaInstitute of Physiology, University of Regensburg, Regensburg, Germany.
Nina WettschureckDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Daniel HenrionLaboratoire MITOVASC, UMR CNRS 6015 - INSERM 1083, Université d'Angers, Angers, France.
Stefan OffermannsDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.ORCID 0000-0001-8676-6805
Max Planck Institute for Heart and Lung Research · DECentre National de la Recherche Scientifique · FRGoethe University Frankfurt · DEHeidelberg University · DEUniversity of Regensburg · DE

Funding

Max-Planck-Gesellschaft Open-access funding
6 · The paper itself

Abstract

Myogenic vasoconstriction is an autoregulatory function of small arteries. Recently, G-protein-coupled receptors have been involved in myogenic vasoconstriction, but the downstream signalling mechanisms and the in-vivo-function of this myogenic autoregulation are poorly understood. Here, we show that small arteries from mice with smooth muscle-specific loss of G

Indexed as

Vascular ResistanceVasoconstrictionAnimalsGTP-Binding Protein alpha Subunits, G12-G13Mice, Inbred C57BLRho Guanine Nucleotide Exchange FactorsArhgef12 protein, mouseGTP-Binding Protein alpha Subunits, G12-G13Rho Guanine Nucleotide Exchange Factorscell biologyG-proteinhuman biologymedicinemousemyogenic tonemyogenic vasoconstrictionRho/Rho-kinasesignal transductionvascular smooth muscle

Identifiers

PMID31549965
PMCPMC6777979
OpenAlexW2975938458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.