Evidence map›Paper›PMID 31549947›Full record

ArticleRadiology2019

Atrophied Brain T2 Lesion Volume at MRI Is Associated with Disability Progression and Conversion to Secondary Progressive Multiple Sclerosis.

Antonia Valentina Genovese, Jesper Hagemeier, Niels Bergsland, Dejan Jakimovski, Michael G Dwyer, Deepa P Ramasamy, Alexis A Lizarraga, David Hojnacki, Channa Kolb, Bianca Weinstock-Guttman and 1 more

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In one paragraph

Article in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

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  20. Neurodegeneration in multiple sclerosis.WIREs mechanisms of disease · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Antonia Valentina GenoveseFrom the Buffalo Neuroimaging Analysis Center (A.V.G., J.H., N.B., D.J., M.G.D., D.P.R., R.Z.) and Jacobs MS Center (A.A.L., D.H., C.K.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY 14203; Institute of Radiology, Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy (A.V.G.); and Center for Biomedical Imaging at Clinical Translational Science Institute (M.G.D., B.W., R.Z.), University at Buffalo, State University of New York, Buffalo, NY.ORCID 0000-0003-3068-4063
Jesper HagemeierFrom the Buffalo Neuroimaging Analysis Center (A.V.G., J.H., N.B., D.J., M.G.D., D.P.R., R.Z.) and Jacobs MS Center (A.A.L., D.H., C.K.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY 14203; Institute of Radiology, Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy (A.V.G.); and Center for Biomedical Imaging at Clinical Translational Science Institute (M.G.D., B.W., R.Z.), University at Buffalo, State University of New York, Buffalo, NY.
Niels BergslandFrom the Buffalo Neuroimaging Analysis Center (A.V.G., J.H., N.B., D.J., M.G.D., D.P.R., R.Z.) and Jacobs MS Center (A.A.L., D.H., C.K.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY 14203; Institute of Radiology, Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy (A.V.G.); and Center for Biomedical Imaging at Clinical Translational Science Institute (M.G.D., B.W., R.Z.), University at Buffalo, State University of New York, Buffalo, NY.ORCID 0000-0002-7792-0433
Dejan JakimovskiFrom the Buffalo Neuroimaging Analysis Center (A.V.G., J.H., N.B., D.J., M.G.D., D.P.R., R.Z.) and Jacobs MS Center (A.A.L., D.H., C.K.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY 14203; Institute of Radiology, Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy (A.V.G.); and Center for Biomedical Imaging at Clinical Translational Science Institute (M.G.D., B.W., R.Z.), University at Buffalo, State University of New York, Buffalo, NY.ORCID 0000-0001-7114-4958
Michael G DwyerFrom the Buffalo Neuroimaging Analysis Center (A.V.G., J.H., N.B., D.J., M.G.D., D.P.R., R.Z.) and Jacobs MS Center (A.A.L., D.H., C.K.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY 14203; Institute of Radiology, Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy (A.V.G.); and Center for Biomedical Imaging at Clinical Translational Science Institute (M.G.D., B.W., R.Z.), University at Buffalo, State University of New York, Buffalo, NY.ORCID 0000-0003-4684-4658
Deepa P RamasamyFrom the Buffalo Neuroimaging Analysis Center (A.V.G., J.H., N.B., D.J., M.G.D., D.P.R., R.Z.) and Jacobs MS Center (A.A.L., D.H., C.K.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY 14203; Institute of Radiology, Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy (A.V.G.); and Center for Biomedical Imaging at Clinical Translational Science Institute (M.G.D., B.W., R.Z.), University at Buffalo, State University of New York, Buffalo, NY.ORCID 0000-0003-0691-5087
Alexis A LizarragaFrom the Buffalo Neuroimaging Analysis Center (A.V.G., J.H., N.B., D.J., M.G.D., D.P.R., R.Z.) and Jacobs MS Center (A.A.L., D.H., C.K.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY 14203; Institute of Radiology, Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy (A.V.G.); and Center for Biomedical Imaging at Clinical Translational Science Institute (M.G.D., B.W., R.Z.), University at Buffalo, State University of New York, Buffalo, NY.
David HojnackiFrom the Buffalo Neuroimaging Analysis Center (A.V.G., J.H., N.B., D.J., M.G.D., D.P.R., R.Z.) and Jacobs MS Center (A.A.L., D.H., C.K.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY 14203; Institute of Radiology, Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy (A.V.G.); and Center for Biomedical Imaging at Clinical Translational Science Institute (M.G.D., B.W., R.Z.), University at Buffalo, State University of New York, Buffalo, NY.
Channa KolbFrom the Buffalo Neuroimaging Analysis Center (A.V.G., J.H., N.B., D.J., M.G.D., D.P.R., R.Z.) and Jacobs MS Center (A.A.L., D.H., C.K.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY 14203; Institute of Radiology, Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy (A.V.G.); and Center for Biomedical Imaging at Clinical Translational Science Institute (M.G.D., B.W., R.Z.), University at Buffalo, State University of New York, Buffalo, NY.
Bianca Weinstock-GuttmanFrom the Buffalo Neuroimaging Analysis Center (A.V.G., J.H., N.B., D.J., M.G.D., D.P.R., R.Z.) and Jacobs MS Center (A.A.L., D.H., C.K.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY 14203; Institute of Radiology, Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy (A.V.G.); and Center for Biomedical Imaging at Clinical Translational Science Institute (M.G.D., B.W., R.Z.), University at Buffalo, State University of New York, Buffalo, NY.
Robert ZivadinovFrom the Buffalo Neuroimaging Analysis Center (A.V.G., J.H., N.B., D.J., M.G.D., D.P.R., R.Z.) and Jacobs MS Center (A.A.L., D.H., C.K.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY 14203; Institute of Radiology, Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy (A.V.G.); and Center for Biomedical Imaging at Clinical Translational Science Institute (M.G.D., B.W., R.Z.), University at Buffalo, State University of New York, Buffalo, NY.ORCID 0000-0002-7799-1485
Jacobs Institute · USUniversity of Pavia · IT

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
NCATS NIH HHS UL1 TR001412
6 · The paper itself

Abstract

Background Atrophied T2 lesion volume at MRI is an imaging measure that reflects the replacement of T2 lesions by cerebrospinal fluid spaces in patients with multiple sclerosis (MS). Purpose To investigate the association of atrophied T2 lesion volume and development of disability progression (DP) and conversion to secondary progressive MS (SPMS). Materials and Methods This retrospective study included 1612 participants recruited from 2006 to 2016 and followed up for 5 years with clinical and MRI examinations. Accumulation of T2 lesion volume, atrophied T2 lesion volume, percentage brain volume change (PBVC), and percentage ventricular volume change (PVVC) were measured. Disability progression and secondary progressive conversion were defined by using standardized guidelines. Analysis of covariance (ANCOVA) adjusted for age and Cox regression adjusted for age and sex were used to compare study groups and explore associations between MRI and clinical outcomes. Results A total of 1314 patients with MS (1006 women; mean age, 46 years ± 11 [standard deviation]) and 124 patients with clinically isolated syndrome (100 women; mean age, 39 years ± 11) along with 147 healthy control subjects (97 women; mean age, 42 years ± 13) were evaluated. A total of 336 of 1314 (23%) patients developed DP, and in 67 of 1213 (5.5%) the disease converted from clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS) to SPMS. Patients with conversion to DP had higher atrophied T2 lesion volume (+34.4 mm

Indexed as

AdultAtrophyDisease ProgressionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple Sclerosis, Chronic ProgressiveRetrospective Studies

Identifiers

PMID31549947
PMCPMC6823621
OpenAlexW2976108714

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.