Evidence map›Paper›PMID 31549719›Full record

ReviewJournal of medical entomology2019

Introduction, Spread, and Establishment of West Nile Virus in the Americas.

Laura D Kramer, Alexander T Ciota, A Marm Kilpatrick

Open access · greenAbstract readReview
In one paragraph

Review in Journal of medical entomology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.

  1. Pooled it
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  18. Review
  19. West Nile virus unmasked: from gene variability to future challenges.Frontiers in cellular and infection microbiology · 2025
    Review
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Laura D KramerThe Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, NY.
Alexander T CiotaThe Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Slingerlands, NY.
A Marm KilpatrickDepartment of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA.
New York State Department of Health · USUniversity of California, Santa Cruz · US

Funding

The Impact of Climate and Climate Change on West Nile Virus TransmissionR01AI090159 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI KILPATRICK, AUSTON MARMADUKE · 2010 to 2013
$1.9M
NCEZID CDC HHS U01 CK000509NCEZID CDC HHS U50 CK000423NIAID NIH HHS R01 AI090159
6 · The paper itself

Abstract

The introduction of West Nile virus (WNV) to North America in 1999 and its subsequent rapid spread across the Americas demonstrated the potential impact of arboviral introductions to new regions, and this was reinforced by the subsequent introductions of chikungunya and Zika viruses. Extensive studies of host-pathogen-vector-environment interactions over the past two decades have illuminated many aspects of the ecology and evolution of WNV and other arboviruses, including the potential for pathogen adaptation to hosts and vectors, the influence of climate, land use and host immunity on transmission ecology, and the difficulty in preventing the establishment of a zoonotic pathogen with abundant wildlife reservoirs. Here, we focus on outstanding questions concerning the introduction, spread, and establishment of WNV in the Americas, and what it can teach us about the future of arboviral introductions. Key gaps in our knowledge include the following: viral adaptation and coevolution of hosts, vectors and the virus; the mechanisms and species involved in the large-scale spatial spread of WNV; how weather modulates WNV transmission; the drivers of large-scale variation in enzootic transmission; the ecology of WNV transmission in Latin America; and the relative roles of each component of host-virus-vector interactions in spatial and temporal variation in WNV transmission. Integrative studies that examine multiple factors and mechanisms simultaneously are needed to advance our knowledge of mechanisms driving transmission.

Indexed as

West Nile FeverWest Nile virusZoonosesAdaptation, BiologicalAnimalsCentral AmericaHost-Pathogen InteractionsHumansNorth AmericaSouth Americaarboviral transmissionarbovirologymosquito-borne diseaseWest Nile Virus

Identifiers

PMID31549719
PMCPMC7182919
OpenAlexW2975329194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.