ArticleThe American journal of tropical medicine and hygiene2019
The Burden of Helminth Coinfections and Micronutrient Deficiencies in Patients with and without Leprosy Reactions: A Pilot Study in Minas Gerais, Brazil.
Article in The American journal of tropical medicine and hygiene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Estimation of Serum Vitamin D Levels and Helminthic Coinfection in Patients with Type 2 Lepra Reactions and its Correlation with Severity of Type 2 Reactions: A Cross-Sectional Study.Indian dermatology online journal · 2025Article
- Spatial associations of Hansen's disease and schistosomiasis in endemic regions of Minas Gerais, Brazil.PLoS neglected tropical diseases · 2024Article
- High-Resolution Plasma Metabolomics Identifies Alterations in Fatty Acid, Energy, and Micronutrient Metabolism in Adults Across the Leprosy Spectrum.The Journal of infectious diseases · 2024Article
- Spatiotemporal pattern of leprosy in southwest China from 2010 to 2020: an ecological study.BMC public health · 2024Observational
- Bacterial, fungal and parasitic co-infections in leprosy: A scoping review.PLoS neglected tropical diseases · 2023Article
- Strongyloidiasis gastritis and colitis in a patient with leprosy.Revista da Sociedade Brasileira de Medicina Tropical · 2022Article
- Associations between occupation, leprosy disability and other sociodemographic factors in an endemic area of Brazil.PLOS global public health · 2022Article
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Authors and funding
20 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leprosy reactions are immune-mediated complications occurring in up to 50% of patients. The immune consequences of helminth infections and micronutrient deficiencies suggest a potential role in type 1 reactions (T1R) or type 2 reactions (T2R). We conducted a case-control study in Minas Gerais, Brazil, to evaluate whether comorbidities and other factors are associated with reactions in patients with multibacillary leprosy. Stool and serum were tested for helminth infections. Deficiencies of vitamin A, D, and iron were measured using serum retinol, 25-hydroxyvitamin D, and ferritin, respectively. Logistic regression models identified associations between reactions and helminth infections, micronutrient deficiencies, and other variables. Seventy-three patients were enrolled, 24 (33%) with T1R, 21 (29%) with T2R, 8 (15%) with mixed T1R/T2R, and 20 (27%) without reactions. Evidence of helminth infections were found in 11 participants (15%) and included IgG4 reactivity against
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