ArticleChemistry, an Asian journal2019
4-Methyltetrahydropyran (4-MeTHP): Application as an Organic Reaction Solvent.
Article in Chemistry, an Asian journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Stable Li Plating/Stripping in LiPF6-Cyclic Ether-Based Electrolytes.Journal of the American Chemical Society · 2026Article
- A tandem conversion process for the synthesis of polyitaconic acid from glucose in the Aspergillus terreus culture.Bioprocess and biosystems engineering · 2025Article
- Calcium Impregnated Silica Gel in the Domino Reaction Involving Irreversible Aldol Addition, Dehydration, and Michael Addition.The Journal of organic chemistry · 2025Article
- Annulative coupling of vinylboronic esters: aryne-triggered 1,2-metallate rearrangement.Chemical science · 2022Article
- Replacement of Less-Preferred Dipolar Aprotic and Ethereal Solvents in Synthetic Organic Chemistry with More Sustainable Alternatives.Chemical reviews · 2022Review
- Olefin Metathesis in Continuous Flow Reactor Employing Polar Ruthenium Catalyst and Soluble Metal Scavenger for Instant Purification of Products of Pharmaceutical Interest.ACS sustainable chemistry & engineering · 2021Article
- Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments.Molecules (Basel, Switzerland) · 2021Article
- The green solvent: a critical perspective.Clean technologies and environmental policy · 2021Review
- 4-Methyltetrahydropyran as a Convenient Alternative Solvent for Olefin Metathesis Reaction: Model Studies and Medicinal Chemistry Applications.ACS sustainable chemistry & engineering · 2020Article
- 4-Methyltetrahydropyran (4-MeTHP): Application as an Organic Reaction Solvent.Chemistry, an Asian journal · 2019Article
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Authors and funding
5 authors.
Funding
Abstract
4-Methyltetrahydropyran (4-MeTHP) is a hydrophobic cyclic ether with potential for industrial applications. We herein report, for the first time, a comprehensive study on the performance of 4-MeTHP as an organic reaction solvent. Its broad application to organic reactions includes radical, Grignard, Wittig, organometallic, halogen-metal exchange, reduction, oxidation, epoxidation, amidation, esterification, metathesis, and other miscellaneous organic reactions. This breadth suggests 4-MeTHP can serve as a substitute for conventional ethers and harmful halogenated solvents. However, 4-MeTHP was found incompatible with strong Lewis acids, and the C-O bond was readily cleaved by treatment with BBr
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.