ArticleJournal of clinical laboratory analysis2020
Serum testosterone/cortisol ratio in people with obstructive sleep apnea.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Obstructive sleep apnea and serum total testosterone: a system review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Association between obstructive sleep apnea and sex hormones in U.S. adult males: a population-based study.Sexual medicine · 2026Article
- Obstructive sleep apnea as a modifier of endocrine toxicities associated with immune checkpoint inhibitors in lung cancer.Frontiers in immunology · 2026Review
- Differential expression profiles and bioinformatics analysis of microRNAs in brown adipose tissue dysfunction induced by chronic intermittent hypoxia in obstructive sleep apnea.Frontiers in cell and developmental biology · 2025Article
- A possible important regulatory role of estrogen in obstructive sleep apnea hypoventilation syndrome.Frontiers in medicine · 2025Review
- Article
- Interactions between Stress Levels and Hormonal Responses Related to Sports Performance in Pro Women's Basketball Team.Journal of functional morphology and kinesiology · 2024Article
- Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea.Biology of sex differences · 2024Article
- Nocturnal hypoxia in patients with sleep disorders: exploring its role as a mediator between neurotic personality traits and psychological symptoms.Frontiers in psychiatry · 2024Article
- Article
- Sleep and Anabolic/Catabolic Hormonal Profile in Sedentary Middle-Aged Adults: The FIT-AGEING Study.International journal of molecular sciences · 2022Article
- High-density lipoprotein cholesterol efflux capacity in patients with obstructive sleep apnea and its relation with disease severity.Lipids in health and disease · 2022Article
- Sarcopenia and nervous system disorders.Journal of neurology · 2022Review
- Associations of testosterone and cortisol concentrations with sleep quality in Japanese male workers.Comprehensive psychoneuroendocrinology · 2022Article
- Prevalence and Characteristics of Erectile Dysfunction in Obstructive Sleep Apnea Patients.Frontiers in endocrinology · 2022Article
- Sleep quality, personal and work variables and life habits of hospital nurses.Revista latino-americana de enfermagem · 2022Article
- Effects of sleep deprivation on sarcopenia and obesity: A narrative review of randomized controlled and crossover trials.Journal of frailty, sarcopenia and falls · 2021Article
- Testosterone Supplementation Induces Age-Dependent Augmentation of the Hypoxic Ventilatory Response in Male Rats With Contributions From the Carotid Bodies.Frontiers in physiology · 2021Article
- Assessment of Screening for Nasal Obstruction among Sleep Dentistry Outpatients with Obstructive Sleep Apnea.Dentistry journal · 2020Article
- Serum testosterone/cortisol ratio in people with obstructive sleep apnea.Journal of clinical laboratory analysis · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesObstructive sleep apnea (OSA) is a major health problem that has been associated with endocrine dysfunction in the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axes. This study investigated cortisol, testosterone, and the testosterone/cortisol ratio in patients with OSA compared to normal sleepers.
methodsThirty-nine OSA patients diagnosed by overnight polysomnography (PSG) were divided into three groups, including ten mild OSA patients, 16 patients with moderate OSA, and 13 patients with severe OSA according to the apnea-hypopnea index (AHI). In addition, 13 normal sleepers with normal PSG findings were recruited as the control group. Serum levels of cortisol, testosterone, and sex hormone-binding globulin (SHBG) were measured using enzyme-linked immunosorbent assay (ELISA).
resultsThere were no significant differences between the normal sleepers and the three subtypes of OSA in terms of total and free testosterone levels (P > .1). The results showed significantly higher levels of cortisol in the severe OSA group compared to the normal sleepers and the two other subtypes of OSA (P < .01). In addition, the testosterone/cortisol (T/C) ratio was significantly lower among the severe OSA compared to the moderate OSA patients (P = .01). A significant correlation was observed between minimal SpO2 and AHI (r=-0.69, P < .01), cortisol and AHI (r = .47, P < .01) and cortisol and minimal SpO2 (r = -.26, P = .06).
conclusionAccording to the findings, OSA is linked to HPA axis activity in severe OSA patients but not among the mild and moderate subtypes of the disorder.
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Registered trials
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