ReviewThe European journal of neuroscience2021
Paternal transgenerational epigenetic mechanisms mediating stress phenotypes of offspring.
Review in The European journal of neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Paternal Depression and Risk of Depression Among Offspring: A Systematic Review and Meta-Analysis.JAMA network open · 2023Pooled it
- Paternal cytokine administration alters sperm small ncRNAs and offspring brain and behavior.Molecular psychiatry · 2026Article
- Sperm sncRNA networks are synchronized by a coordination between adverse childhood experiences (ACE) and current stress.Scientific reports · 2026Article
- Paternal predatory risk alters parental behavior and offspring phenotypes in biparental Brandt's voles.Current zoology · 2025Article
- Grandfathers-to-Grandsons Transgenerational Transmission of Exercise Positive Effects on Cognitive Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Stress in the social context: a behavioural and eco-evolutionary perspective.The Journal of experimental biology · 2023Review
- Paternal Western diet causes transgenerational increase in food consumption in Drosophila with parallel alterations in the offspring brain proteome and microRNAs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Paternal transgenerational nutritional epigenetic effect: A new insight into nutritional manipulation to reduce the use of antibiotics in animal feeding.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Canada's Colonial Genocide of Indigenous Peoples: A Review of the Psychosocial and Neurobiological Processes Linking Trauma and Intergenerational Outcomes.International journal of environmental research and public health · 2022Review
- Cocaine-Induced Changes in SpermThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Neurobiological Correlates of Fatherhood During the Postpartum Period: A Scoping Review.Frontiers in psychology · 2022Article
- Epigenetics and the International Classification of Functioning, Disability and Health Model: Bridging Nature, Nurture, and Patient-Centered Population Health.Physical therapy · 2022Article
- Trends in Research of Prenatal Stress From 2011 to 2021: A Bibliometric Study.Frontiers in pediatrics · 2022Article
- Maternal High-Fat Diet ModulatesNutrients · 2021Article
- Cardinal role of the environment in stress induced changes across life stages and generations.Neuroscience and biobehavioral reviews · 2021Review
- A Glimpse Into the Sexual Dimorphisms in Major Depressive Disorder Through Epigenetic Studies.Frontiers in neural circuits · 2021Review
- Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases.International journal of genomics · 2021Review
- Brain and placental transcriptional responses as a readout of maternal and paternal preconception stress are fetal sex specific.Placenta · 2020Article
- The relevance of a rodent cohort in the Consortium on Individual Development.Developmental cognitive neuroscience · 2020Article
- Intermittent Hypoxia Promotes Functional Neuroprotection from Retinal Ischemia in Untreated First-Generation Offspring: Proteomic Mechanistic Insights.Investigative ophthalmology & visual science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Depression and anxiety risk are highly influenced by both genetic and environmental factors. Recently, it has been proposed that epigenetic mechanisms may also contribute to the transmission of both depression- and anxiety-related behaviors across multiple generations. This review highlights long-lasting epigenetic alterations observed in offspring of fathers, including some distinct effects on male and female offspring, in animal models. Available evidence emphasizes how both the developmental time point and the type of paternal stress (social vs. asocial) influence the complex transmission patterns of these phenotypes to future generations. This research is critical in understanding the factors that influence risk for depression and anxiety disorders and has the potential to contribute to the development of innovative treatments that can more precisely target vulnerable populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.