ArticleAnnals of biomedical engineering2020
Platelet Dynamics and Hemodynamics of Cerebral Aneurysms Treated with Flow-Diverting Stents.
Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Determining flow stasis zones in the intracranial aneurysms and the relation between these zones and aneurysms' aspect ratios after flow diversions.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Key influencers in an aneurysmal thrombosis model: A sensitivity analysis and validation study.APL bioengineering · 2025Article
- Endothelial Cell Transcription Modulation in Cerebral Aneurysms After Endovascular Flow Diversion.Annals of biomedical engineering · 2024Article
- Standardized viscosity as a source of error in computational fluid dynamic simulations of cerebral aneurysms.Medical physics · 2024Article
- Hemodynamics of thrombus formation in intracranial aneurysms: AnAPL bioengineering · 2023Article
- Improving the accuracy of computational fluid dynamics simulations of coiled cerebral aneurysms using finite element modeling.Journal of biomechanics · 2023Article
- Modeling the Mechanical Microenvironment of Coiled Cerebral Aneurysms.Journal of biomechanical engineering · 2023Article
- Investigating Angiographic Injection Parameters for Cerebral Aneurysm Hemodynamic Characterization Using Patient-Specific Simulated Angiograms.Proceedings of SPIE--the International Society for Optical Engineering · 2023Article
- Endothelial Responses to Curvature-Induced Flow Patterns in Engineered Cerebral Aneurysms.Journal of biomechanical engineering · 2023Article
- The effect of Dean, Reynolds and Womersley numbers on the flow in a spherical cavity on a curved round pipe. Part 2. The haemodynamics of intracranial aneurysms treated with flow-diverting stents.Journal of fluid mechanics · 2021Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Flow-diverting stents (FDS) are used to treat cerebral aneurysms. They promote the formation of a stable thrombus within the aneurysmal sac and, if successful, isolate the aneurysmal dome from mechanical stresses to prevent rupture. Platelet activation, a mechanism necessary for thrombus formation, is known to respond to biomechanical stimuli, particularly to the platelets' residence time and shear stress exposure. Currently, there is no reliable method for predicting FDS treatment outcomes, either a priori or after the procedure. Eulerian computational fluid dynamic (CFD) studies of aneurysmal flow have searched for predictors of endovascular treatment outcome; however, the hemodynamics of thrombus formation cannot be fully understood without considering the platelets' trajectories and their mechanics-triggered activation. Lagrangian analysis of the fluid mechanics in the aneurysmal vasculature provides novel metrics by tracking the platelets' residence time (RT) and shear history (SH). Eulerian and Lagrangian parameters are compared for 19 patient-specific cases, both pre- and post-treatment, to assess the degree of change caused by the FDS and subsequent treatment efficacy.
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