ArticleIntensive care medicine2019
Feasibility and safety of ultra-low tidal volume ventilation without extracorporeal circulation in moderately severe and severe ARDS patients.
Article in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02816372 (Ultra Protective Ventilation Without Extracorporeal Circulation in Severe ARDS Patients), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ultra Protective Ventilation Without Extracorporeal Circulation in Severe ARDS Patients (VT4ARDS)
Who cites it
20 citing papers in PubMed.
- Impact of ultra-low tidal volume ventilation on 1-year functional outcome in COVID-19 ARDS patients. A long-term follow-up analysis of a randomized controlled trial.Critical care (London, England) · 2026Trial
- Effect of a driving pressure-limiting strategy for patients with acute respiratory distress syndrome secondary to community-acquired pneumonia: the STAMINA randomised clinical trial.British journal of anaesthesia · 2025Trial
- Ultra-low versus low tidal volume ventilation in acute respiratory distress syndrome: a systematic review and meta-analysis.Journal of thoracic disease · 2026Article
- A prospective clinical evaluation of new ECCO2R technology in mild to moderate ARDS patients: assessing ultra-lung-protective ventilation with PRISMALUNG.Critical care (London, England) · 2026Article
- Case Report: Electrical impedance tomography-guided ultra-protective lung ventilation during veno-venous extracorporeal membrane oxygenation support for fat embolism syndrome complicated by severe acute respiratory distress syndrome.Frontiers in medicine · 2026Article
- Lung-protective ventilation strategy in acute respiratory distress syndrome: a critical reappraisal of current practice.Critical care (London, England) · 2025Review
- Advancing extracorporeal carbon dioxide removal technology: bridging basic science and clinical practice.Medical gas research · 2025Review
- The role of extracorporeal COFrontiers in medicine · 2025Review
- Respiratory extracorporeal membrane oxygenation : From rescue therapy to standard tool for treatment of acute respiratory distress syndrome?Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- Intermediate tidal volume is an acceptable option for ventilated patients with acute respiratory distress syndrome.Medicina intensiva · 2022Article
- Intermediate tidal volume is an acceptable option for ventilated patients with acute respiratory distress syndrome.Medicina intensiva · 2022Article
- Article
- The Staying Power of Pressure- and Volume-limited Ventilation in Acute Respiratory Distress Syndrome.American journal of respiratory and critical care medicine · 2021Article
- A rational approach on the use of extracorporeal membrane oxygenation in severe hypoxemia: advanced technology is not a panacea.Annals of intensive care · 2021Review
- Personalized Positive End-Expiratory Pressure and Tidal Volume in Acute Respiratory Distress Syndrome: Bedside Physiology-Based Approach.Critical care explorations · 2021Review
- Hypercapnia in the critically ill: insights from the bench to the bedside.Interface focus · 2021Review
- The use of extracorporeal COAnnals of intensive care · 2021Review
- Extracorporeal life support for adults with acute respiratory distress syndrome.Intensive care medicine · 2020Review
- The acute respiratory distress syndrome.Proceedings (Baylor University. Medical Center) · 2020Article
- Protective ventilation from ICU to operating room: state of art and new horizons.Korean journal of anesthesiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMechanical ventilation with ultra-low tidal volume (VT) during ARDS may reduce alveolar strain, driving pressure and hence ventilator-induced lung injury, with the main drawback of worsening respiratory acidosis. We hypothesized that VT could be reduced down to 4 ml/kg, with clinically significant decrease in driving pressure, without the need for extracorporeal CO
methodsWe conducted a non-experimental before-and-after multicenter study on 35 ARDS patients with PaO
resultsFrom inclusion to day 2, driving pressure decreased significantly from 12 [9-15] to 8 [6-11] cmH
conclusionUltra-low tidal volume ventilation may be applied in approximately 2/3 of moderately severe-to-severe ARDS patients, with a 4 cmH
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.