Evidence map›Paper›PMID 31549181›Full record

ArticlePediatric surgery international2020

The effect of APTR, Fn14 and CD133 expressions on liver fibrosis in biliary atresia patients.

Akhmad Makhmudi, Reinaldo Supanji, Bayu Pratama Putra, Gunadi

Abstract read
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In one paragraph

Article in Pediatric surgery international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Evaluation of the effect of therapeutic plasma exchange on serum cytokine levels in pediatric intensive care unit.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
    Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Serum TGF-Computational and mathematical methods in medicine · 2022
    Article
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Akhmad MakhmudiPediatric Surgery Division, Department of Surgery/Genetics Working Group, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Jl. Kesehatan No. 1, Yogyakarta, 55281, Indonesia.
Reinaldo SupanjiPediatric Surgery Division, Department of Surgery/Genetics Working Group, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Jl. Kesehatan No. 1, Yogyakarta, 55281, Indonesia.
Bayu Pratama PutraPediatric Surgery Division, Department of Surgery/Genetics Working Group, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Jl. Kesehatan No. 1, Yogyakarta, 55281, Indonesia.
GunadiPediatric Surgery Division, Department of Surgery/Genetics Working Group, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Jl. Kesehatan No. 1, Yogyakarta, 55281, Indonesia. drgunadi@ugm.ac.id.ORCID http://orcid.org/0000-0002-4707-6526
Universitas Gadjah Mada · ID

Funding

Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada UPPM/220/M/05/04/05.17Faculty of Medicine, Public Health and Nursing, Universitas Gadjah MAda UPPM/363/M/05/04/05.18
6 · The paper itself

Abstract

purposeAlthough some biomarkers of hepatic progenitor cells have been reported to be involved in the liver fibrosis in patients with biliary atresia (BA), however, research still shows conflicting results. Therefore, we investigated the effect of Alu-mediated p21 transcriptional regulator (APTR), fibroblast growth factor-inducible 14 (Fn14) and CD133 expressions on liver fibrosis in Indonesian BA patients.

methodsNineteen liver samples from BA patients and 9 liver specimens from non-BA controls were obtained. The expressions of APTR, Fn14 and CD133 were analyzed by quantitative real-time polymerase chain reaction (qPCR).

resultsAPTR expression was strongly up-regulated (1.5-fold) in liver BA specimens compared to liver controls (ΔC

conclusionWe present the first study of aberrant APTR expressions in the liver of BA infants which might contribute to liver fibrogenesis in BA infants.

Indexed as

AC133 AntigenBiliary AtresiaBiomarkersCase-Control StudiesFemaleHumansInfantLiverLiver CirrhosisMaleReal-Time Polymerase Chain ReactionRNA, Long NoncodingTWEAK ReceptorUp-RegulationAC133 AntigenBiomarkerslong non-coding RNA APTR, humanPROM1 protein, humanRNA, Long NoncodingTNFRSF12A protein, humanTWEAK ReceptorAberrant expressionAPTRBiliary atresiaIndonesiaLiver fibrosisqPCR

Identifiers

PMID31549181
OpenAlexW2976666996

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.