Evidence map›Paper›PMID 31549178›Full record

Trial reportHeart and vessels2020

Prasugrel effectively reduces the platelet reactivity units in patients with genetically metabolic dysfunction of cytochrome P450 2C19 who are treated with long-term dual antiplatelet therapy after undergoing drug-eluting stent implantation.

Junichiro Shimamatsu, Ken-Ichiro Sasaki, Yoshio Katsuki, Tomohiro Kawasaki, Yoshinobu Murasato, Hidehiko Ajisaka, Hiroyoshi Yokoi, Hideki Tashiro, Atsushi Harada, Yuji Hirakawa and 6 more

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Heart and vessels, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Junichiro ShimamatsuDivision of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Fukuoka, Japan.
Ken-Ichiro SasakiDivision of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Fukuoka, Japan.
Yoshio KatsukiDivision of Cardiology, Sugi Hospital, Omuta, Japan.
Tomohiro KawasakiDepartment of Cardiology, Cardiovascular Center, Shin Koga Hospital, Kurume, Japan.
Yoshinobu MurasatoDepartment of Cardiology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Hidehiko AjisakaDivision of Cardiovascular Internal Medicine, Asakura Medical Association Hospital, Asakura, Japan.
Hiroyoshi YokoiDivision of Cardiovascular Internal Medicine, Fukuoka Sanno Hospital, Fukuoka, Japan.
Hideki TashiroDivision of Cardiovascular Internal Medicine, St. Mary's Hospital, Kurume, Japan.
Atsushi HaradaDaiichi Sankyo Co., Ltd., Tokyo, Japan.
Yuji HirakawaDaiichi Sankyo Co., Ltd., Tokyo, Japan.
Yuta IshizakiDivision of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Fukuoka, Japan.
Takashi IshimatsuDivision of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Fukuoka, Japan.
Kotaro KagiyamaDivision of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Fukuoka, Japan.
Yoshihiro FukumotoDivision of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Fukuoka, Japan.
Tatsuyuki KakumaBiostatistics Center, Kurume University, Kurume, Japan.
Takafumi UenoDivision of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Fukuoka, Japan. takueno@med.kurume-u.ac.jp.ORCID http://orcid.org/0000-0001-7222-9128
Kurume University · JPDaiichi-Sankyo (Japan) · JPFukuoka Hospital · JPJapan Hospital Association · JPKoga Hospital · JPNational Kyushu Medical Center · JPSt Mary's Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dual antiplatelet therapy (DAPT) with aspirin and P2Y

Indexed as

Drug-Eluting StentsDrug SubstitutionPharmacogenomic VariantsPolymorphism, Single NucleotideAdultAgedAged, 80 and overAspirinClopidogrelCoronary Artery DiseaseCytochrome P-450 CYP2C19Drug ResistanceDual Anti-Platelet TherapyFemaleHumansJapanAspirinClopidogrelCYP2C19 protein, humanCytochrome P-450 CYP2C19Platelet Aggregation InhibitorsPrasugrel HydrochloridePurinergic P2Y Receptor AntagonistsClopidogrelDrug changeGenetic polymorphismPercutaneous coronary intervention

Identifiers

PMID31549178
PMCPMC7026273
OpenAlexW2976082004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.