Evidence map›Paper›PMID 31549145›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020

Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults.

Cutter A Lindbergh, Kaitlin B Casaletto, Adam M Staffaroni, Fanny Elahi, Samantha M Walters, Michelle You, John Neuhaus, Will Rivera Contreras, Paul Wang, Anna Karydas and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
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  8. Astrocytes in aging.Neuron · 2025
    Review
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  15. Immune cell counts in cerebrospinal fluid predict cognitive function in aging and neurodegenerative disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Cutter A LindberghDepartment of Neurology, Memory and Aging Center and , California.
Kaitlin B CasalettoDepartment of Neurology, Memory and Aging Center and , California.
Adam M StaffaroniDepartment of Neurology, Memory and Aging Center and , California.
Fanny ElahiDepartment of Neurology, Memory and Aging Center and , California.
Samantha M WaltersDepartment of Neurology, Memory and Aging Center and , California.
Michelle YouDepartment of Neurology, Memory and Aging Center and , California.
John NeuhausDepartment of Epidemiology and Biostatistics, University of California at San Francisco, California.
Will Rivera ContrerasDepartment of Neurology, Memory and Aging Center and , California.
Paul WangDepartment of Neurology, Memory and Aging Center and , California.
Anna KarydasDepartment of Neurology, Memory and Aging Center and , California.
Jesse BrownDepartment of Neurology, Memory and Aging Center and , California.
Amy WolfDepartment of Neurology, Memory and Aging Center and , California.
Howie RosenDepartment of Neurology, Memory and Aging Center and , California.
Yann CobigoDepartment of Neurology, Memory and Aging Center and , California.
Joel H KramerDepartment of Neurology, Memory and Aging Center and , California.
University Memory and Aging Center · USUniversity of California, San Francisco · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, YADONG · 2004 to 2018
$27.1M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Multidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4M
Effects of chronic inflammation on brain structure and functionR01AG048234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2015 to 2019
$3.2M
Multimodal Imaging in Frontotemporal DegenerationK24AG045333 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2013 to 2023
$1.9M
Can Behavior Shape Neural Health? Identifying Modifiable Factors to Prevent Cognitive Decline in AgeK23AG058752 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2018 to 2022
$994k
Patient-tailored network prediction of neurodegenerative disease progressionK01AG055698 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BROWN, JESSE AARON · 2017 to 2022
$779k
NIA NIH HHS K01 AG055698NIA NIH HHS K23 AG058752NIA NIH HHS K24 AG045333NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG048234NIA NIH HHS T32 AG023481
6 · The paper itself

Abstract

backgroundCentral nervous system levels of tumor necrosis factor-alpha (TNF-α), a pro-inflammatory cytokine, regulate the neuroinflammatory response and may play a role in age-related neurodegenerative diseases. The longitudinal relation between peripheral levels of TNF-α and typical brain aging is understudied. We hypothesized that within-person increases in systemic TNF-α would track with poorer brain health outcomes in functionally normal adults.

methodsPlasma-based TNF-α concentrations (pg/mL; fasting morning draws) and magnetic resonance imaging were acquired in 424 functionally intact adults (mean age = 71) followed annually for up to 8.4 years (mean follow-up = 2.2 years). Brain outcomes included total gray matter volume and white matter hyperintensities. Cognitive outcomes included composites of memory, executive functioning, and processing speed, as well as Mini-Mental State Examination total scores. Longitudinal mixed-effects models were used, controlling for age, sex, education, and total intracranial volume, as appropriate.

resultsTNF-α concentrations significantly increased over time (p < .001). Linear increases in within-person TNF-α were longitudinally associated with declines in gray matter volume (p < .001) and increases in white matter hyperintensities (p = .003). Exploratory analyses suggested that the relation between TNF-α and gray matter volume was curvilinear (TNF-α 2p = .002), such that initial increases in inflammation were associated with more precipitous atrophy. There was a negative linear relationship of within-person changes in TNF-α to Mini-Mental State Examination scores over time (p = .036) but not the cognitive composites (all ps >.05).

conclusionSystemic inflammation, as indexed by plasma TNF-α, holds potential as a biomarker for age-related declines in brain health.

Indexed as

AgedAgingBiomarkersCognitionExecutive FunctionFemaleFollow-Up StudiesGray MatterHumansMagnetic Resonance ImagingMaleMemory, EpisodicNeuropsychological TestsTumor Necrosis Factor-alphaWhite MatterBiomarkersTumor Necrosis Factor-alphaBrain agingCognitionGray matter volumeInflammationNeuroimaging

Identifiers

PMID31549145
PMCPMC7457183
OpenAlexW2977189296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.