Evidence map›Paper›PMID 31548890›Full record

ArticleEnvironmental science. Nano2018

Biodissolution and Cellular Response to MoO3 Nanoribbons and a New Framework for Early Hazard Screening for 2D Materials.

Evan P Gray, Cynthia L Browning, Mengjing Wang, Kyle D Gion, Eric Y Chao, Kristie J Koski, Agnes B Kane, Robert H Hurt

Abstract read
In one paragraph

Article in Environmental science. Nano, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Chemical and Colloidal Dynamics of MnOSmall (Weinheim an der Bergstrasse, Germany) · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Evan P GrayThe School of Engineering, Brown University, Providence RI, 02912, United States. robert_hurt@brown.edu.
Cynthia L BrowningThe Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence RI, 02912, United States. agnes_kane@brown.edu.
Mengjing WangThe Department of Chemistry, Brown University, 156 George Street, Providence RI, 02912, United States.
Kyle D GionThe School of Engineering, Brown University, Providence RI, 02912, United States. robert_hurt@brown.edu.
Eric Y ChaoThe School of Engineering, Brown University, Providence RI, 02912, United States. robert_hurt@brown.edu.
Kristie J KoskiDepartment of Chemistry, University of California Davis, 1 Shields Ave. Davis CA 95616. koski@ucdavis.edu.
Agnes B KaneThe Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Providence RI, 02912, United States. agnes_kane@brown.edu.
Robert H HurtThe School of Engineering, Brown University, Providence RI, 02912, United States. robert_hurt@brown.edu.

Funding

Vapor Pressures and Thermodynamic Properties of Complex Organic MixturesP42ES013660 · NIEHS · BROWN UNIVERSITY · PI BOEKELHEIDE, KIM · 2005 to 2020
$37.7M
NIEHS NIH HHS P42 ES013660
6 · The paper itself

Abstract

Two-dimensional (2D) materials are a broad class of synthetic ultra-thin sheet-like solids whose rapid pace of development motivates systematic study of their biological effects and safe design. A challenge for this effort is the large number of new materials and their chemical diversity. Recent work suggests that many 2D materials will be thermodynamically unstable and thus non-persistent in biological environments. Such information could inform and accelerate safety assessment, but experimental data to confirm the thermodynamic predictions is lacking. Here we propose a framework for early hazard screening of nanosheet materials based on biodissolution studies in reactive media, specially chosen for each material to match chemically feasible degradation pathways. Simple dissolution and in vitro tests allow grouping of nanosheet materials into four classes: A, potentially biopersistent; B: slowly degradable (>24-48 hours); C, biosoluble with potentially hazardous degradation products; and D, biosoluble with low-hazard degradation products. The proposed framework is demonstrated through an experimental case study on MoO

Identifiers

PMID31548890
PMCPMC6756761

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.