Evidence map›Paper›PMID 31548805›Full record

ReviewCurrent oncology (Toronto, Ont.)2019

Emerging therapies for the treatment of relapsed or refractory diffuse large B cell lymphoma.

P Skrabek, S Assouline, A Christofides, D MacDonald, A Prica, R Sangha, B A Matthews, L H Sehn

Abstract readReview
In one paragraph

Review in Current oncology (Toronto, Ont.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  5. CAR T-cell Therapy for Diffuse Large B-cell Lymphoma in Canada: A Cost-Utility Analysis.Medical decision making : an international journal of the Society for Medical Decision Making · 2024
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  15. 2018-2019 Drug Updates in Hematologic Malignancies.Journal of the advanced practitioner in oncology · 2020
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

P SkrabekDepartment of Hematology and Medical Oncology, University of Manitoba, and CancerCare Manitoba, Winnipeg, MB.
S AssoulineDepartment of Medicine, Division of Hematology, Sir Mortimer B. Davis Jewish General Hospital and McGill University, Montreal, QC.
A ChristofidesimpactMedicom Inc., Toronto, ON.
D MacDonaldThe Ottawa Hospital, Ottawa, ON.
A PricaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre, and University of Toronto, Toronto, ON.
R SanghaUniversity of Alberta and Cross Cancer Institute, Edmonton, AB.
B A MatthewsHoffmann-La Roche, Mississauga, ON.
L H SehnDivision of Medical Oncology, University of British Columbia, and BC Cancer, Vancouver, BC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse large B cell lymphoma (dlbcl) is an aggressive non-Hodgkin lymphoma, accounting for approximately 30% of lymphoma cases in Canada. Although most patients will achieve a cure, up to 40% will experience refractory disease after initial treatment, or relapse after a period of remission. In eligible patients, salvage therapy followed by high-dose therapy and autologous stem-cell transplantation (asct) is the standard of care. However, many patients are transplant-ineligible, and more than half of those undergoing asct will subsequently relapse. For those patients, outcomes are dismal, and novel treatment approaches are a critical unmet need. In this paper, we present available data about emerging treatment approaches in the latter setting and provide a perspective about the potential use of those approaches in Canada.

Indexed as

AdenineAntibodies, MonoclonalAntineoplastic AgentsBrentuximab VedotinCanadaClinical Trials as TopicHumansImmunoconjugatesLymphoma, Large B-Cell, DiffuseNeoplasm Recurrence, LocalPiperidinesPyrazolesPyrimidinesAdenineAntibodies, MonoclonalAntineoplastic AgentsBrentuximab VedotinibrutinibImmunoconjugatesPiperidinespolatuzumab vedotinPyrazolesPyrimidinesDiffuse large B cell lymphomadlbclnon-Hodgkin lymphomanovel therapies

Identifiers

PMID31548805
PMCPMC6726277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.