ArticleScientific reports2019
Characterization of drug resistance and genetic diversity of Plasmodium falciparum parasites from Tripura, Northeast India.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Molecular surveillance of antimalarial drug resistance genes in Nigeria: a systematic review and roadmap to malaria elimination.BMC medical genomics · 2025Pooled it
- Systematic Review and Geospatial Modeling of Molecular Markers of Resistance to Artemisinins and Sulfadoxine-Pyrimethamine in Plasmodium falciparum in India.The American journal of tropical medicine and hygiene · 2024Pooled it
- Genetic diversity and population structure of Plasmodium falciparum across areas of varied malaria transmission intensities in Uganda.Malaria journal · 2025Article
- Genetic diversity ofCurrent research in parasitology & vector-borne diseases · 2025Article
- Plasmodium falciparum genetic diversity and multiplicity of infection among asymptomatic and symptomatic malaria-infected individuals in Uganda.Tropical medicine and health · 2024Article
- Force of Infection (FOI) and Multiplicity of Infection (MOI) inPathogens (Basel, Switzerland) · 2024Article
- Assessment of Epidemiological Indicators for Evaluation of National Malaria Elimination Programme: A Retrospective Study.Ethiopian journal of health sciences · 2023Article
- Molecular detection of drug-resistantThe Indian journal of medical research · 2023Article
- Molecular surveillance of anti-malarial drug resistance genes in Plasmodium falciparum isolates in Odisha, India.Malaria journal · 2022Article
- Genetic polymorphism ofAccess microbiology · 2022Article
- Multi-Omics Advancements towardsDiagnostics (Basel, Switzerland) · 2021Review
- Evidence of a Recent Bottleneck inPathogens (Basel, Switzerland) · 2021Article
- Population structure and diversity of Plasmodium falciparum in children with asymptomatic malaria living in different ecological zones of Ghana.BMC infectious diseases · 2021Article
- Genetic diversity and complexity of Plasmodium falciparum infections in the microenvironment among siblings of the same household in North-Central Nigeria.Malaria journal · 2020Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Monitoring of anti-malarial drug resistance is vital in Northeast India as this region shares its international border with Southeast Asia. Genetic diversity of Plasmodium parasites regulates transmission dynamics, disease severity and vaccine efficacy. P. falciparum chloroquine resistance transporter (Pfcrt), multidrug resistance-1 (Pfmdr-1) and kelch 13 propeller (PfK-13) genes which govern antimalarial drug resistance and three genetic diversity markers, merozoite surface protein 1 and 2 (Pfmsp-1, Pfmsp-2) and glutamate rich protein (Pfglurp) were evaluated from Tripura, Northeast India using molecular tools. In the Pfcrt gene, 87% isolates showed triple mutations at codons M74I, N75E and K76T. 12.5% isolates in Pfmdr-1 gene showed mutation at N86Y. No polymorphism in PfK-13 propeller was found. Polyclonal infections were observed in 53.85% isolates and more commonly in adults (p = 0.0494). In the Pfmsp-1 locus, the K1 allelic family was predominant (71.2%) followed by the 3D7/IC family (69.2%) in the Pfmsp-2 locus. RII region of Pfglurp exhibited nine alleles with expected heterozygosity of 0.85. The multiplicity of infection for Pfmsp-1, Pfmsp-2 and Pfglurp were 1.56, 1.31 and 1.06 respectively. Overall, the study demonstrated a high level of chloroquine resistance and extensive parasite diversity in the region, necessitating regular surveillance in this population group.
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