ArticleScientific reports2019
Early exercise induces long-lasting morphological changes in cortical and hippocampal neurons throughout of a sedentary period of rats.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Physical activity stimulates neurogenesis via sensory neuron activity in postembryonic zebrafish.iScience · 2026Article
- Higher physical activity levels mitigate synaptic protein loss and cognitive deterioration in aging and in Alzheimer's disease: a 10-year longitudinal study.Molecular biomedicine · 2026Article
- Increasing the health span: unique role for exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Swimming Training Prevents Stress-Induced Spatial Memory Impairment by Reducing Neurodegenerative Changes in Hippocampus.Biochemistry research international · 2025Article
- Adulthood effects of developmental exercise in rats.Developmental psychobiology · 2024Article
- Neurocognitive effects of stress: a metaparadigm perspective.Molecular psychiatry · 2023Review
- Review
- Hippocampal Adaptations to Continuous Aerobic Training: A Functional and Ultrastructural Evaluation in a Young Murine Model.Journal of functional morphology and kinesiology · 2021Article
- Understanding the role of aerobic fitness, spatial learning, and hippocampal subfields in adolescent males.Scientific reports · 2021Article
- Lactate as Potential Mediators for Exercise-Induced Positive Effects on Neuroplasticity and Cerebrovascular Plasticity.Frontiers in physiology · 2021Review
- Role of Regular Physical Activity in Neuroprotection against Acute Ischemia.International journal of molecular sciences · 2020Review
- Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration.International journal of molecular sciences · 2020Review
- A Unique Mouse Model of Early Life Exercise Enables Hippocampal Memory and Synaptic Plasticity.Scientific reports · 2020Article
- Three-Week Treadmill Exercise Enhances Persistent Inward Currents, Facilitates Dendritic Plasticity, and Upregulates the Excitability of Dorsal Raphe Serotonin Neurons in ePet-EYFP Mice.Frontiers in cellular neuroscience · 2020Article
- Comparative overview of the effects of aerobic and resistance exercise on anxiety-like behavior, cognitive flexibility, and hippocampal synaptic plasticity parameters in healthy rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
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11 authors.
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Abstract
Life experiences at early ages, such as physical activity in childhood and adolescence, can result in long-lasting brain effects able to reduce future risk of brain disorders and to enhance lifelong brain functions. However, how early physical exercise promotes these effects remains unclear. A possible hypothesis is that physical exercise increases the expression of neurotrophic factors and stimulates neuronal growth, resulting in a neural reserve to be used at later ages. Basing our study on this hypothesis, we evaluated the absolute number and morphology of neuronal cells, as well as the expression of growth, proliferation and survival proteins (BDNF, Akt, mTOR, p70S6K, ERK and CREB) in the cerebral cortex and hippocampal formation throughout of a sedentary period of rats who were physically active during youth. To do this, male Wistar rats were submitted to an aerobic exercise protocol from the 21
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