ReviewInternational journal of obesity (2005)2019
Hypothalamic neuronal cellular and subcellular abnormalities in experimental obesity.
Review in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Maternal pre-pregnancy body mass index is associated with newborn offspring hypothalamic mean diffusivity: a prospective dual-cohort study.BMC medicine · 2023Article
- Maternal free fatty acid concentration during pregnancy is associated with newborn hypothalamic microstructure in humans.Obesity (Silver Spring, Md.) · 2022Article
- Interleukin-6 actions in the hypothalamus protects against obesity and is involved in the regulation of neurogenesis.Journal of neuroinflammation · 2021Article
- Acute physical exercise increases PI3K-p110α protein content in the hypothalamus of obese mice.Journal of anatomy · 2021Article
- Gut-to-brain signals in feeding control.American journal of physiology. Endocrinology and metabolism · 2021Review
- Modulation of neural fMRI responses to visual food cues by overeating and fasting interventions: A preliminary study.Physiological reports · 2021Article
- We could be better if we ate better.Archives of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characterization of the hypothalamic neuronal network, that controls food intake and energy expenditure, has provided great advances in the understanding of the pathophysiology of obesity. Most of the advances in this field were obtained thanks to the development of a number of genetic and nongenetic animal models that, at least in part, overtook the anatomical constraints that impair the study of the human hypothalamus. Despite the undisputed differences between human and rodent physiology, most seminal studies undertaken in rodents that have unveiled details of the neural regulation of energy homeostasis were eventually confirmed in humans; thus, placing experimental studies in the forefront of obesity research. During the last 15 years, researchers have provided extensive experimental proof that supports the existence of hypothalamic dysfunction, which leads to a progressive whole-body positive energy balance, and thus, to obesity. Here, we review the experimental work that unveiled the mechanisms behind hypothalamic dysfunction in obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.