Evidence map›Paper›PMID 31548430›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Mast cells are critical for controlling the bacterial burden and the healing of infected wounds.

C Zimmermann, D Troeltzsch, V A Giménez-Rivera, S J Galli, M Metz, M Maurer, F Siebenhaar

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 89 citations in OpenAlex.

  1. Review
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  13. The Skin Microbiome: Current Landscape and Future Opportunities.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Article
  16. Review
  17. Do mast cells contribute to the continued survival of vertebrates?APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022
    Review
  18. Article
  19. TheiScience · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

C ZimmermannDermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
D TroeltzschDermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
V A Giménez-RiveraDermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
S J GalliDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5176.
M MetzDermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.ORCID 0000-0002-4070-9976
M MaurerDermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.ORCID 0000-0002-4121-481X
F SiebenhaarDermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany; frank.siebenhaar@charite.de.ORCID 0000-0003-4532-1644
Humboldt-Universität zu Berlin · DEStanford Medicine · US

Funding

Role of nociceptive sensory neuron/mast cell interactions in cutaneous allergic inflammationR01AI132494 · NIAID · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 2017 to 2021
$2.4M
RabGEF1 in MyD88 signaling, skin immunity, and atopic dermatitisR01AR067145 · NIAMS · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 2015 to 2019
$1.9M
NIAID NIH HHS R01 AI132494NIAMS NIH HHS R01 AR067145
6 · The paper itself

Abstract

Skin wound infections are a significant health problem, and antibiotic resistance is on the rise. Mast cells (MCs) have been shown to contribute to host-defense responses in certain bacterial infections, but their role in skin wound superinfection is unknown. We subjected 2 MC-deficient mouse strains to

Indexed as

AnimalsAnti-Bacterial AgentsCells, CulturedHumansInterleukin-6KeratinocytesMast CellsMicePseudomonas aeruginosaPseudomonas InfectionsSkinWound HealingWound InfectionAnti-Bacterial AgentsInterleukin-6bacterial infectioninnate immunitymast cellspseudomonas aeruginosaskin wound infection

Identifiers

PMID31548430
PMCPMC6789730
OpenAlexW2976830222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.