ArticleProceedings of the National Academy of Sciences of the United States of America2019
Early detection and monitoring of cerebral ischemia using calcium-responsive MRI probes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Liposomal nanoprobes actuated by engineered water channels for sensitive detection of molecular targets by MRI.Nature biomedical engineering · 2026Article
- Automatic design and optimization of MRI-based neurochemical sensors via reinforcement learning.Discover nano · 2025Article
- The role of responsive MRI probes in the past and the future of molecular imaging.Chemical science · 2024Review
- A Reactive and Specific Sensor for Activity-BasedACS sensors · 2024Article
- Texaphyrin-Based Calcium Sensor for Multimodal Imaging.ACS sensors · 2023Article
- Structural and functional imaging of brains.Science China. Chemistry · 2023Review
- Sustained delivery of focal ischemia coupled to real-time neurochemical sensing in brain slices.Lab on a chip · 2022Article
- Molecular fMRI of neurochemical signaling.Journal of neuroscience methods · 2021Review
- Fast Ion-Chelate Dissociation Rate forJournal of the American Chemical Society · 2021Article
- RGD-Peptide Functionalization Affects theJournal of medicinal chemistry · 2021Article
- Calcium-responsive contrast agents for functional magnetic resonance imaging.Chemical physics reviews · 2021Review
- Monitoring and Prognostic Analysis of Severe Cerebrovascular Diseases Based on Multi-Scale Dynamic Brain Imaging.Frontiers in neuroscience · 2021Article
- Temporal Progression of Excitotoxic Calcium Following Distal Middle Cerebral Artery Occlusion in Freely Moving Mice.Frontiers in cellular neuroscience · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral ischemia is one of the leading causes of mortality and disability in infants and adults and its timely diagnosis is essential for an efficient treatment. We present a methodology for fast detection and real-time monitoring of fluctuations of calcium ions associated with focal ischemia using a molecular functional MRI approach. We used a dinuclear paramagnetic gadolinium(III) complex chelate that changes MR image contrast through its reversible interaction with extracellular calcium ions, while applying a remote transient middle cerebral artery occlusion as a model for ischemic stroke. Our method sensitively recognizes the onset and follows the dynamics of the ischemic core and penumbra with submillimeter spatial and second-scale temporal resolution, thus paving the way for noninvasive monitoring and development of targeted treatment strategies for cerebral ischemia.
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