Evidence map›Paper›PMID 31548399›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

SerpinB1 controls encephalitogenic T helper cells in neuroinflammation.

Lifei Hou, Deepak A Rao, Koichi Yuki, Jessica Cooley, Lauren A Henderson, A Helena Jonsson, Dion Kaiserman, Mark P Gorman, Peter A Nigrovic, Phillip I Bird and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Review
  3. Pro-Inflammatory c-MetAnnals of neurology · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Innate acting memory Th1 cells modulate heterologous diseases.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Terminally differentiated cytotoxic CD4CNS neuroscience & therapeutics · 2024
    Article
  13. Article
  14. Article
  15. IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Lifei HouThe Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115; lifei.hou@childrens.harvard.edu eremold@gmail.com.
Deepak A RaoDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115.
Koichi YukiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA 02115.
Jessica CooleyThe Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
Lauren A HendersonDepartment of Pediatrics, Harvard Medical School, Boston, MA 02115.
A Helena JonssonDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115.
Dion KaisermanDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Mark P GormanDepartment of Pediatrics, Harvard Medical School, Boston, MA 02115.
Peter A NigrovicDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115.
Phillip I BirdDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Burkhard BecherInflammation Unit, Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland.ORCID 0000-0002-1541-7867
Eileen Remold-O'DonnellThe Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115; lifei.hou@childrens.harvard.edu eremold@gmail.com.ORCID 0000-0001-5197-1390
Boston Children's Hospital · USBrigham and Women's Hospital · USAustralian Regenerative Medicine Institute · AUUniversity of Zurich · CH

Funding

Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
Ly6 family members in neutrophil biologyR01AR065538 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2014 to 2024
$4.0M
The Reprogramming of Regulatory T cells to a Th17 Phenotype in Systemic Juvenile Idiopathic ArthritisK08AR073339 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI HENDERSON, LAUREN A · 2018 to 2022
$840k
Molecular control of CD4 T cell ability to help B cellsK08AR072791 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI RAO, DEEPAK ANGARA · 2018 to 2022
$764k
Regulation of Th17 immune responses by serpinB1R21AI117440 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI REMOLD-O'DONNELL, EILEEN · 2016 to 2017
$487k
NIAID NIH HHS R21 AI117440NIAMS NIH HHS K08 AR072791NIAMS NIH HHS K08 AR073339NIAMS NIH HHS P30 AR070253NIAMS NIH HHS R01 AR065538
6 · The paper itself

Abstract

SerpinB1, a protease inhibitor and neutrophil survival factor, was recently linked with IL-17-expressing T cells. Here, we show that

Indexed as

AnimalsCD4-Positive T-LymphocytesCytokinesEncephalomyelitis, Autoimmune, ExperimentalInterferon-gammaMiceMice, Inbred C57BLMice, KnockoutReceptors, CXCR6SerpinsT-Lymphocytes, Helper-InducerCxcr6 protein, mouseCytokinesInterferon-gammaReceptors, CXCR6Serpinb1a protein, mouseSerpinsautoimmuneinflammatory arthritismultiple sclerosispathogenic T helper cellsserpins

Identifiers

PMID31548399
PMCPMC6789640
OpenAlexW2977072567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.