ArticleProceedings of the National Academy of Sciences of the United States of America2019
A self-assembled Ru-Pt metallacage as a lysosome-targeting photosensitizer for 2-photon photodynamic therapy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 148 citations in OpenAlex.
- Recent Advances in Two-Photon-Activatable Metal Complexes for Photodynamic Therapy.Angewandte Chemie (International ed. in English) · 2026Review
- Development of a Nucleoside Photosensitizer Efficiently Activated by One- or Two-Photon Absorption in the Optical Therapeutic Window.Journal of the American Chemical Society · 2026Article
- Heterometallic Multinuclear Ruthenium Complexes as Cytotoxic Agents.Biomedicines · 2026Review
- Architecting NIR-II metal supramolecular dyes-illuminating the path to precision medicine.Chemical science · 2026Review
- Recent advances in nanomedicine design strategies for targeting subcellular structures.iScience · 2025Review
- Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics.Small methods · 2024Review
- A Highly Charged Positive Cage Causes Simultaneous Enhancement of Type-II and OSmall science · 2024Article
- Self-Assembled Iron(III) Coordination Cage as an MRI-Active Carrier for a Gold(I) Drug.Bioconjugate chemistry · 2024Article
- Hierarchically Assembled Gigantic Fe/Co Cyanometallate Clusters Exhibiting Electron Transfer Behavior Above Room Temperature.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Organo-PtAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Review of the application of the most current sophisticated image processing methods for the skin cancer diagnostics purposes.Archives of dermatological research · 2024Review
- Interrogating bioinspired ESIPT/PCET-based Ir(iii)-complexes as organelle-targeted phototherapeutics: a redox-catalysis under hypoxia to evoke synergistic ferroptosis/apoptosis.Chemical science · 2023Article
- Acceptor engineering of metallacycles with high phototoxicity indices for safe and effective photodynamic therapy.Chemical science · 2023Article
- Phosphorescent Metal Halide Nanoclusters for Tunable Photodynamic Therapy.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- PET Imaging of Self-AssembledChemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Ferroptosis promotes sonodynamic therapy: a platinum(ii)-indocyanine sonosensitizer.Chemical science · 2022Article
- Long wavelength-emissive Ru(II) metallacycle-based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Fluorescein-Based Type I Supramolecular Photosensitizer via Induction of Charge Separation by Self-Assembly.JACS Au · 2022Article
- Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy.Nature communications · 2022Article
- Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications.Nature communications · 2022Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Photodynamic therapy (PDT) is a treatment procedure that relies on cytotoxic reactive oxygen species (ROS) generated by the light activation of a photosensitizer. The photophysical and biological properties of photosensitizers are vital for the therapeutic outcome of PDT. In this work a 2D rhomboidal metallacycle and a 3D octahedral metallacage were designed and synthesized via the coordination-driven self-assembly of a Ru(II)-based photosensitizer and complementary Pt(II)-based building blocks. The metallacage showed deep-red luminescence, a large 2-photon absorption cross-section, and highly efficient ROS generation. The metallacage was encapsulated into an amphiphilic block copolymer to form nanoparticles to encourage cell uptake and localization. Upon internalization into cells, the nanoparticles selectively accumulate in the lysosomes, a favorable location for PDT. The nanoparticles are almost nontoxic in the dark, and can efficiently destroy tumor cells via the generation of ROS in the lysosomes under 2-photon near-infrared light irradiation. The superb PDT efficacy of the metallacage-containing nanoparticles was further validated by studies on 3D multicellular spheroids (MCS) and in vivo studies on A549 tumor-bearing mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.