ArticleeNeuro
The Reuniens Nucleus of the Thalamus Has an Essential Role in Coordinating Slow-Wave Activity between Neocortex and Hippocampus.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Infraslow modulation of theta synchrony in the hippocampus circuit during REM sleep.Scientific reports · 2026Article
- Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Hippocampal-Prelimbic Coupling During Context-Dependent Extinction Retrieval in Rats.Hippocampus · 2026Article
- The thalamic nucleus reuniens orchestrates prefrontal-hippocampal synchrony in memory, emotion, and disease.Frontiers in behavioral neuroscience · 2026Review
- Isolated theta waves originating from the midline thalamus trigger memory reactivation during NREM sleep in mice.Nature communications · 2024Article
- An ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits.Communications biology · 2024Article
- Neural circuits for the adaptive regulation of fear and extinction memory.Frontiers in behavioral neuroscience · 2024Review
- Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall.Current biology : CB · 2023Article
- Pathological changes of brain oscillations following ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Review
- Neuronal circuitry for recognition memory of object and place in rodent models.Neuroscience and biobehavioral reviews · 2022Review
- Thalamo-hippocampal pathway regulates incidental memory capacity in mice.Nature communications · 2022Article
- Dual medial prefrontal cortex and hippocampus projecting neurons in the paraventricular nucleus of the thalamus.Brain structure & function · 2022Article
- Hippocampal-medial prefrontal cortex network dynamics predict performance during retrieval in a context-guided object memory task.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Pathways for Memory, Cognition and Emotional Context: Hippocampal, Subgenual Area 25, and Amygdalar Axons Show Unique Interactions in the Primate Thalamic Reuniens Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Neural Oscillations in Aversively Motivated Behavior.Frontiers in behavioral neuroscience · 2022Review
- Thalamic volume and fear extinction interact to predict acute posttraumatic stress severity.Journal of psychiatric research · 2021Observational
- Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function.Neuropsychology review · 2021Review
- Medial prefrontal cortex (A32 and A25) projections in the common marmoset: a subcortical anterograde study.Scientific reports · 2021Article
- Calretinin and calbindin architecture of the midline thalamus associated with prefrontal-hippocampal circuitry.Hippocampus · 2021Article
- Network Asynchrony Underlying Increased Broadband Gamma Power.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep is a period of profound neural synchrony throughout the brain, a phenomenon involved in various physiological functions. The coordination between neocortex and hippocampus, in particular, appears to be critical for episodic memory, and, indeed, enhanced synchrony in this circuit is a hallmark of slow-wave sleep. However, it is unclear how this coordination is mediated. To this end, we examined the role of the thalamic nucleus reuniens (RE), a midline body with reciprocal connections to both prefrontal and hippocampal cortices. Using a combination of electrophysiological, optogenetic, and chemogenetic techniques in the urethane-anesthetized rat (a model of forebrain sleep activity), we directly assessed the role of the RE in mediating slow oscillatory synchrony. Using unit recording techniques, we confirmed that RE neurons showed slow rhythmic activity patterns during deactivated forebrain states that were coupled to ongoing slow oscillations. Optogenetic activation of RE neurons or their projection fibers in the cingulum bundle caused an evoked potential in hippocampus that was maximal at the level of stratum lacunosum-moleculare of CA1. A similar but longer-latency response could be evoked by stimulation of the medial prefrontal cortex that was then abolished by chemogenetic inhibition of the RE. Inactivation of the RE also severely reduced the coherence of the slow oscillation across cortical and hippocampal sites, suggesting that its activity is necessary to couple slow-wave activity across these regions. These results indicate an essential role of the RE in coordinating neocortico-hippocampal slow oscillatory activity, which may be fundamental for slow-wave sleep-related episodic memory consolidation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.