Evidence map›Paper›PMID 31548330›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8

Xenia Ficht, Nora Ruef, Bettina Stolp, Guerric P B Samson, Federica Moalli, Nicolas Page, Doron Merkler, Ben J Nichols, Alba Diz-Muñoz, Daniel F Legler and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The roles of FLOT1 in human diseases (Review).Molecular medicine reports · 2023
    Review
  5. Article
  6. Article
  7. Pre-organized landscape of T cell surface.Frontiers in immunology · 2023
    Review
  8. Review
  9. Immunogenetics of Lupus Erythematosus.Advances in experimental medicine and biology · 2022
    Article
  10. Review
  11. Observational
  12. Membrane Compartmentalization and Scaffold Proteins in Leukocyte Migration.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

Xenia FichtTheodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.
Nora RuefDepartment of Oncology, Microbiology and Immunology, University of Fribourg, 1700 Fribourg, Switzerland.ORCID 0000-0001-5211-3363
Bettina StolpTheodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.
Guerric P B SamsonBiotechnology Institute Thurgau at the University of Konstanz, 8280 Kreuzlingen, Switzerland.ORCID 0000-0002-4505-6409
Federica MoalliTheodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0002-8426-2571
Nicolas PageDepartment of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.
Doron MerklerDepartment of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.
Ben J NicholsMedical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Alba Diz-MuñozCell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany; and.ORCID 0000-0001-6864-8901
Daniel F LeglerBiotechnology Institute Thurgau at the University of Konstanz, 8280 Kreuzlingen, Switzerland.ORCID 0000-0001-8610-4764
Verena NiggliInstitute of Pathology, University of Bern, 3008 Bern, Switzerland.
Jens V SteinDepartment of Oncology, Microbiology and Immunology, University of Fribourg, 1700 Fribourg, Switzerland; jens.stein@unifr.ch.ORCID 0000-0002-8199-9586
University of Bern · CHBiotechnology Institute Thurgau · CHUniversity of Fribourg · CHUniversity of Geneva · CHEuropean Molecular Biology Laboratory · DEMRC Laboratory of Molecular Biology · GB

Funding

Swiss National Science Foundation 172994
6 · The paper itself

Abstract

Flotillin-1 (Flot1) is an evolutionary conserved, ubiquitously expressed lipid raft-associated scaffolding protein. Migration of Flot1-deficient neutrophils is impaired because of a decrease in myosin II-mediated contractility. Flot1 also accumulates in the uropod of polarized T cells, suggesting an analogous role in T cell migration. In this study, we analyzed morphology and migration parameters of murine wild-type and Flot1

Indexed as

AnimalsCD8-Positive T-LymphocytesCell MovementEpidermisFemaleImmunologic MemoryLymphocyte ActivationMaleMembrane MicrodomainsMembrane ProteinsMiceMice, Inbred C57BLflotillinsMembrane Proteins

Identifiers

PMID31548330
PMCPMC6820809
OpenAlexW2977214322

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.