Evidence map›Paper›PMID 31548329›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Biased S1PR1 Signaling in B Cells Subverts Responses to Homeostatic Chemokines, Severely Disorganizing Lymphoid Organ Architecture.

Il-Young Hwang, Chung Park, Kathleen Harrison, John H Kehrl

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05245344 (Effects of Ozanimod on Immune-mediated Mechanisms of Neurodegeneration in Multiple Sclerosis - a Preclinical Study), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05245344 unknown statusnot on this mapstarted 2022, after this paper: background citation

Effects of Ozanimod on Immune-mediated Mechanisms of Neurodegeneration in Multiple Sclerosis - a Preclinical Study

TypeobservationalSponsorNeuromed IRCCSRan2022 to 2023Enrolled154ConditionsRelapsing-Remitting Multiple Sclerosis (RRMS), Neuromyelitis Optica, HealthyArmsPeripheral blood withdrawal
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Il-Young HwangB Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Chung ParkB Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-7819-5333
Kathleen HarrisonB Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
John H KehrlB Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 jkehrl@niaid.nih.gov.ORCID 0000-0002-6526-159X
National Institutes of Health · US

Funding

CONTROL OF G PROTEIN SIGNALING: ROLE OF THE RGSSZ01AI000738 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI KEHRL, JOHN H · 1996 to 2008
$3.9M
Intramural NIH HHS Z01 AI000738
6 · The paper itself

Abstract

Ligand-engaged chemoattractant receptors trigger Gα

Indexed as

HomeostasisAnimalsB-LymphocytesCalciumCell MovementChemokine CXCL13G-Protein-Coupled Receptor Kinase 2LeukocytosisLymphoid TissueLysophospholipidsMiceMice, Inbred C57BLReceptors, ChemokineReceptors, CXCR4Signal TransductionSphingosineCalciumChemokine CXCL13Cxcl13 protein, mouseCXCR4 protein, mouseG-Protein-Coupled Receptor Kinase 2GRK2 protein, mouseLysophospholipidsReceptors, ChemokineReceptors, CXCR4S1pr1 protein, mouseSphingosinesphingosine 1-phosphateSphingosine-1-Phosphate Receptors

Identifiers

PMID31548329
PMCPMC6814389
OpenAlexW2975681649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.