Evidence map›Paper›PMID 31548322›Full record

ArticleInfection and immunity2019

Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis.

Jeongho Park, Jonathan H DeLong, James J Knox, Christoph Konradt, Elia D Tait Wojno, Christopher A Hunter

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Interleukins 30 and 27 in psoriasis and inflammation.Postepy dermatologii i alergologii · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jeongho ParkUniversity of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-0340-9181
Jonathan H DeLongUniversity of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA.
James J KnoxUniversity of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Christoph KonradtUniversity of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA.
Elia D Tait WojnoUniversity of Washington, Department of Immunology, Seattle, Washington, USA.
Christopher A HunterUniversity of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA chunter@vet.upenn.edu.ORCID 0000-0003-3092-1428
University of Pennsylvania · USUniversity of Washington · US

Funding

TRAINING PROGRAM/RHEUMATIC DISEASEST32AR007442 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI BEHRENS, EDWARD M, MERKEL, PETER A · 1986 to 2018
$5.8M
IMMUNOPATHOGENESIS OF TOXOPLASMIC ENCEPHALITISR01AI041158 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 1996 to 2019
$4.8M
Impact of early T-bet on CD8 T cell effector responsesR01AI125563 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 2016 to 2020
$2.0M
IL-27 and Treg cellsR01AI110201 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 2014 to 2018
$2.0M
NIAID NIH HHS R01 AI041158NIAID NIH HHS R01 AI110201NIAID NIH HHS R01 AI125563NIAMS NIH HHS T32 AR007442
6 · The paper itself

Abstract

Interleukin-27 (IL-27) is a heterodimeric cytokine composed of the subunits IL-27p28 and EBi3, and while the IL-27 heterodimer influences T cell activities, there is evidence that IL-27p28 can have EBi3-independent activities; however, their relevance to infection is unclear. Therefore, the studies presented here compared how IL-27p28 transgenics and IL-27p28

Indexed as

AnimalsAntibodies, ProtozoanB-LymphocytesCentral Nervous SystemFemaleInterleukinsMaleMiceMice, Inbred C57BLT-LymphocytesToxoplasmaToxoplasmosisAntibodies, ProtozoanIl27 protein, mouseInterleukinsantibodiesantibodyIL-27inflammationT cellToxoplasma

Identifiers

PMID31548322
PMCPMC6867838
OpenAlexW2975222847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.